943439-55-2Relevant articles and documents
Benzothiophene selective estrogen receptor modulators with modulated oxidative activity and receptor affinity
Qin, Zhihui,Kastrati, Irida,Chandrasena, R. Esala P.,Liu, Hong,Yao, Ping,Petukhov, Pavel A.,Bolton, Judy L.,Thatcher, Gregory R. J.
, p. 2682 - 2692 (2008/02/07)
The regulation of estrogenic and antiestrogenic effects of selective estrogen receptor modulators (SERMs) is thought to underlie their clinical use. Most SERMs are polyaromatic phenols susceptible to oxidative metabolism to quinoids, which are proposed to