94353-40-9

Basic information

• Product Name: N-ACETYL-5-CHLOROINDOLE
• Synonyms: N-ACETYL-5-CHLOROINDOLE
• CAS NO: 94353-40-9
• Molecular Formula: C10H8ClNO
• Molecular Weight: 193.632
• Mol File: 94353-40-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-ACETYL-5-CHLOROINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: N-ACETYL-5-CHLOROINDOLE(94353-40-9)
• EPA Substance Registry System: N-ACETYL-5-CHLOROINDOLE(94353-40-9)

Safety Data

• Hazardous Substances Data: 94353-40-9(Hazardous Substances Data)

Upstream product

• 108-05-4 vinyl acetate 
• 1503-91-9 N-(4-chlorophenyl)-N-hydroxyacetamide 
• 17422-32-1 5-chloro-1H-indole 
• 108-24-7 acetic anhydride 
• 872-36-6 vinylene carbonate 
• 539-03-7 N-(4-chlorophenyl)acetamide 

Relevant articles and documents

Rhodium-Catalyzed Annulative Coupling Using Vinylene Carbonate as an Oxidizing Acetylene Surrogate

Transition-metal-catalyzed C-H activation and subsequent oxidative cyclization with alkynes has been a powerful tool for the synthesis of polycyclic aromatic compounds. Despite the substantial progress in this field, it is still a significant challenge to establish synthetic methodologies for the construction of nonsubstituted vinylene-fused aromatics. We herein report a Rh(III)-catalyzed C-H/N-H annulation with vinylene carbonate as an acetylene surrogate. Vinylene carbonate also acts as an internal oxidant to regenerate the Rh(III) species in situ; thus, no external oxidant is required to trigger the oxidative annulation. This protocol is applicable to the direct synthesis of various N-heteroaromatics.

192. Synthese von 2,3-unsubstituierten, N-acylierten Indolen durch sigmatrope-Umlagerung von O-Vinyl-N-phenylhydroxylaminderivaten

Treatment of N-phenylhydroxamic acids with vinylacetate in the presence of Li2PdCl4 affords 2,3-unsubstituted N-acylindoles via hetero-Cope-rearrangement of the intermediate N-phenyl-O-vinylhydroxylamine derivatives.