94359-88-3Relevant articles and documents
NEW SYNTHETIC "TRICKS". TRIPHENYLPHOSPHINE-MEDIATED AMIDE FORMATION FROM CARBOXYLIC ACIDS AND AZIDES
Garcia, Jordi,Urpi, Felix,Villarasa, Jaume
, p. 4841 - 4844 (2007/10/02)
Equimolar amounts of carboxylic acids, aryl or alkyl azides, and Ph3P in refluxing benzene (hexane, toluene) afford amides in good yields.Insolubility of zwitterions Ph3P(+)-NH(CH2)nCOO(-), arising from ω-azido acids and Ph3P, limits the utilization of the method for lactame formation.