943634-38-6

Basic information

• Product Name: C₄₇H₃₉FN₄O₂
• Synonyms: C₄₇H₃₉FN₄O₂
• CAS NO: 943634-38-6
• Molecular Weight: 710.851
• Mol File: 943634-38-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₇H₃₉FN₄O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₇H₃₉FN₄O₂(943634-38-6)
• EPA Substance Registry System: C₄₇H₃₉FN₄O₂(943634-38-6)

Safety Data

• Hazardous Substances Data: 943634-38-6(Hazardous Substances Data)

Upstream product

• 77811-44-0 4-bromo-2-methyl-6-nitroaniline 
• 76153-06-5 5-bromo-3-methylbenzene-1,2-diamine 
• 468741-09-5 (S)-4-(1-Benzyl-2-trityloxy-ethylamino)-3-(6-bromo-4-methyl-1H-benzimidazol-2-yl)-1H-pyridin-2-one 
• 1765-93-1 4-fluoroboronic acid 
• 468741-08-4 (S)-4-(1-benzyl-2-hydroxy-ethylamino)-3-(6-bromo-4-methyl-1H-benzimidazol-2-yl)-1H-pyridin-2-one 
• 943634-36-4 C₁₃H₉BrIN₃O 
• 468741-06-2 6-bromo-2-(4-iodo-2-methoxy-pyridin-3-yl)-4-methyl-1H-benzimidazole 

Relevant articles and documents

Imidazole moiety replacements in the 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) to improve cytochrome P450 profile

A series of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) were examined in which the pendant imidazole moiety was replaced to improve selectivity for IGF-1R inhibition over cytochrome P450 (CYP). Synthesis and SAR of these compounds is presented.