94367-20-1 Usage
Description
SUC-LEU-TYR-AMC is a synthetic peptide substrate that consists of a succinyl-leucyl-tyrosyl side-chain attached to a coumarin molecule carrying a methyl group at C-4. It serves as a fluorescent substrate for calpain I and II, as well as papain, and is utilized to measure the peptidase activity of the 20S proteasome.
Uses
Used in Pharmaceutical and Biomedical Research:
SUC-LEU-TYR-AMC is used as a research tool for assessing the activity of specific proteases, such as calpain I and II, and papain. Its application aids in understanding the role of these enzymes in various biological processes and their potential as therapeutic targets.
Used in Drug Development:
SUC-LEU-TYR-AMC is employed as a screening agent in drug discovery to identify potential inhibitors or activators of the targeted proteases. This helps in the development of new therapeutic agents that can modulate the activity of these enzymes for treating various diseases.
Used in Quality Control and Diagnostics:
In the biotechnology and pharmaceutical industries, SUC-LEU-TYR-AMC is used as a quality control standard to ensure the accuracy and reliability of assays and tests designed to measure protease activity. It also serves as a diagnostic tool to assess the functionality of the 20S proteasome in various disease states.
Check Digit Verification of cas no
The CAS Registry Mumber 94367-20-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,4,3,6 and 7 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 94367-20:
(7*9)+(6*4)+(5*3)+(4*6)+(3*7)+(2*2)+(1*0)=151
151 % 10 = 1
So 94367-20-1 is a valid CAS Registry Number.
InChI:InChI=1/C29H33N3O8/c1-4-16(2)27(32-24(34)11-12-25(35)36)29(39)31-22(14-18-5-8-20(33)9-6-18)28(38)30-19-7-10-21-17(3)13-26(37)40-23(21)15-19/h5-10,13,15-16,22,27,33H,4,11-12,14H2,1-3H3,(H,30,38)(H,31,39)(H,32,34)(H,35,36)/t16?,22?,27-/m0/s1
