94385-00-9Relevant articles and documents
Mechanism-based design of simple, symmetrical, easily prepared, potent antimalarial endoperoxides
Posner, Gary H.,Wang, Dasong,Gonzalez, Lluisa,Tao, Xueliang,Cumming, Jared N.,Klinedinst, Donna,Shapiro, Theresa A.
, p. 815 - 818 (2007/10/03)
Mechanism-based design, two-step synthesis, and in vitro antimalarial testing showed thermally stable, crystalline, bicyclic endoperoxides 2a and 2b to be potent antimalarials. Their reduction by FeBr2 proceeds via oxy-radicals and then carbon