943994-74-9

Basic information

• Product Name: Methyl 2-(4-broMo-2-Methyl-6-nitrophenoxy)acetate
• Synonyms: Methyl 2-(4-broMo-2-Methyl-6-nitrophenoxy)acetate
• CAS NO: 943994-74-9
• Molecular Formula: C10H10BrNO5
• Molecular Weight: 304.0941
• Mol File: 943994-74-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Methyl 2-(4-broMo-2-Methyl-6-nitrophenoxy)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-(4-broMo-2-Methyl-6-nitrophenoxy)acetate(943994-74-9)
• EPA Substance Registry System: Methyl 2-(4-broMo-2-Methyl-6-nitrophenoxy)acetate(943994-74-9)

Safety Data

• Hazardous Substances Data: 943994-74-9(Hazardous Substances Data)

Usage

Description

Methyl 2-(4-bromo-2-methyl-6-nitrophenoxy)acetate is a chemical compound with the molecular formula C11H12BrNO5. It is a yellow crystalline solid that is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. This phenoxyacetic acid derivative contains a phenoxy group and an acetate group, with the presence of bromo and nitro substituents on the phenyl ring, making it a versatile building block for the construction of various complex molecules.

Uses

Used in Pharmaceutical Synthesis:
Methyl 2-(4-bromo-2-methyl-6-nitrophenoxy)acetate is used as an intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into complex molecular structures, contributing to the development of new drugs.
Used in Agrochemical Synthesis:
It is also used as an intermediate in the synthesis of agrochemicals, particularly due to its structural similarity to known compounds used in agriculture, such as pesticides or herbicides.
Used in Organic Synthesis:
Methyl 2-(4-bromo-2-methyl-6-nitrophenoxy)acetate is utilized as a versatile building block in organic synthesis, allowing for the creation of a wide range of complex molecules for various applications across different industries.

Upstream product

• 20294-50-2 4-bromo-2-methyl-6-nitrophenol 
• 96-32-2 bromoacetic acid methyl ester 

Downstream Products

• 121564-97-4 6-bromo-8-methyl-2H-1,4-benzoxazin-3(4H)-one 
• 943994-87-4 8-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-1,4-benzoxazin-3(4H)-one 
• 1221500-65-7 6-[5-(4-fluorophenyl)-1,3-dimethyl-1H-pyrazol-4-yl]-8-methyl-2H-1,4-benzoxazin-3(4H)-one 

Relevant articles and documents

Discovery of 6-[5-(4-fluorophenyl)-3-methyl-pyrazol-4-yl]-benzoxazin-3-one derivatives as novel selective nonsteroidal mineralocorticoid receptor antagonists

In the course of our study on selective nonsteroidal mineralocorticoid receptor (MR) antagonists, a series of novel benzoxazine derivatives possessing an azole ring as the core scaffold was designed for the purpose of attenuating the partial agonistic activity of the previously reported dihydropyrrol-2-one derivatives. Screening of alternative azole rings identified 1,3-dimethyl pyrazole 6a as a lead compound with reduced partial agonistic activity. Subsequent replacement of the 1-methyl group of the pyrazole ring with larger lipophilic side chains or polar side chains targeting Arg817 and Gln776 increased MR binding activity while maintaining the agonistic response at the lower level. Among these compounds, 6-[1-(2,2-difluoro-3-hydroxypropyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one (37a) showed highly potent in vitro activity, high selectivity versus other steroid hormone receptors, and good pharmacokinetic profiles. Oral administration of 37a in deoxycorticosterone acetate-salt hypertensive rats showed a significant blood pressure-lowering effect with no signs of antiandrogenic effects.

FUSED HETEROCYCLIC COMPOUND AND USE THEREOF

The present invention relates to wherein each symbol is as defined in the specification. The compound has a superior mineral corticoidreceptorantagonistic action and is useful as an agent for the prophylaxis or treatment of hypertension, cardiac failure and the like, a compound having a fused heterocycle, or a prodrug thereof, or a salt thereof; and an agent for the prophylaxis or treatment of hypertension, cardiac failure and the like.