944140-66-3

Basic information

• Product Name: C₂₂H₃₂N₂O₆
• Synonyms: C₂₂H₃₂N₂O₆
• CAS NO: 944140-66-3
• Molecular Weight: 420.506
• Mol File: 944140-66-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₂₂H₃₂N₂O₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₃₂N₂O₆(944140-66-3)
• EPA Substance Registry System: C₂₂H₃₂N₂O₆(944140-66-3)

Safety Data

• Hazardous Substances Data: 944140-66-3(Hazardous Substances Data)

Upstream product

• 157226-76-1 1-tert-butyl 3,5-dimethyl piperidine-1,3,5-tricarboxylate 
• 170564-98-4 (R)-3-amino-3-phenyl-1-propanol 
• 499-81-0 3,5-Pyridinedicarboxylic acid 
• 534572-17-3 (3R,5S)-1-(tert-butoxycarbonyl)piperidine-3,5-dicarboxylic acid 
• 191544-71-5 1-(tert-butoxycarbonyl)-3-(methoxycarbonyl)piperidine-5-carboxylic acid 

Downstream Products

• 944140-65-2 C₂₁H₃₀N₂O₆ 

Relevant articles and documents

Structure-based design of substituted piperidines as a new class of highly efficacious oral direct renin inhibitors

A cis-configured 3,5-disubstituted piperidine direct renin inhibitor, (syn,rac)-1, was discovered as a high-throughput screening hit from a target-family tailored library. Optimization of both the prime and the nonprime site residues flanking the central piperidine transition-state surrogate resulted in analogues with improved potency and pharmacokinetic (PK) properties, culminating in the identification of the 4-hydroxy-3,5-substituted piperidine 31. This compound showed high in vitro potency toward human renin with excellent off-target selectivity, 60% oral bioavailability in rat, and dose-dependent blood pressure lowering effects in the double-transgenic rat model.