94420-55-0

Basic information

• Product Name: Benzoic acid, 2-hydroxy-5-[(tetrahydro-2H-pyran-2-yl)oxy]-, methyl ester
• CAS NO: 94420-55-0
• Molecular Formula: C13H16O5
• Molecular Weight: 252.267
• Mol File: 94420-55-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-hydroxy-5-[(tetrahydro-2H-pyran-2-yl)oxy]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-hydroxy-5-[(tetrahydro-2H-pyran-2-yl)oxy]-, methyl ester(94420-55-0)
• EPA Substance Registry System: Benzoic acid, 2-hydroxy-5-[(tetrahydro-2H-pyran-2-yl)oxy]-, methyl ester(94420-55-0)

Safety Data

• Hazardous Substances Data: 94420-55-0(Hazardous Substances Data)

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 2150-46-1 Methyl 2,5-dihydroxybenzoate 

Downstream Products

• 94420-45-8 2-methoxymethyl-4-(2'-tetrahydropyranyloxy)anisol 
• 94420-57-2 2-methoxy-5-(2'-tetrahydropyranyloxy)phenylmethanol 
• 7715-19-7 2-(methoxymethyl)-1,4-benzoquinone 
• 59907-65-2 4-methoxy-3-(methoxymethyl)phenol 
• 179915-23-2 (1S,2R,6R)-1-(5-Methoxy-2-methoxymethoxy-benzyl)-2,6-dimethyl-2-((E)-4-methyl-penta-1,3-dienyl)-cyclohexanol 
• 179749-27-0 2-[(R)-2,6-Dimethyl-6-((E)-4-methyl-penta-1,3-dienyl)-cyclohex-1-enylmethyl]-4-methoxy-1-methoxymethoxy-benzene 
• 144033-76-1 5-Hydroxy-2-methoxymethoxy-benzoic acid methyl ester 
• 179749-15-6 2-Chloromethyl-4-methoxy-1-methoxymethoxy-benzene 
• 179749-31-6 (5-methoxy-2-(methoxymethoxy)phenyl)-methan-1-ol 
• 51985-42-3 methyl 5-methoxy-2-(methoxymethyloxy)benzoate 
• 945989-86-6 C₁₆H₁₈ClNO₂ 
• 1002331-29-4 C₂₁H₂₆ClNO₃ 

Relevant articles and documents

A new class of histamine H3 receptor antagonists derived from ligand based design

Design and synthesis of highly potent and selective non-imidazole inverse agonists for the histamine H3 receptor is described. The study validates a new pharmacophore model based on the merging of two previously described models. It also demonstrates that the removal of the basic center potentially interacting with ASP3.32 and common to both models leads to loss of activity, whereas the replacement of the second basic center by an acceptor retains the potency.

Preparation of Regioselectively Protected Hydroquinones by Phosphorylation of p-Benzoquinones with Trialkyl Phosphites

The title reaction has been applied to 10 monosubstituted p-benzoquinones (Scheme 2, Table).The regioselectivity of the O-phosphorylation is influenced by bulky substituents (t-butyl and trimethylsilyl) and, electronically, by the methoxy group.The regioselectivity, which is high in nonpolar media (benzene), is lower in polar solvents (CH2Cl2 and CH3CN).The synthetic potential of this transformation, exemplified by the preparation of compounds 29 (Scheme 3) and 32 (Scheme 4), is considerably extended by applying milder methods for the phosphate hydrolysis and by using the reagent couple P(OCH3)3/trimethylsilyl chloride, which gives clean access to p-hydroxyphenyl phosphates. p-Benzoquinones 4h and 4i with strong ?-acceptor substituents react in a different way, giving phosphonates.The electronically induced regioselectivity of the O- and C-phosphorylation is in accordance with the preferences expected for the attack by a nucleophilic phosphorylation agent.