944325-18-2

Basic information

• Product Name: (S)-(+)-1-cyano-1-cyclopentyl-1-phenylmethyl hydroxyacetate
• CAS NO: 944325-18-2
• Molecular Weight: 259.305
• Mol File: 944325-18-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-(+)-1-cyano-1-cyclopentyl-1-phenylmethyl hydroxyacetate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(+)-1-cyano-1-cyclopentyl-1-phenylmethyl hydroxyacetate(944325-18-2)
• EPA Substance Registry System: (S)-(+)-1-cyano-1-cyclopentyl-1-phenylmethyl hydroxyacetate(944325-18-2)

Safety Data

• Hazardous Substances Data: 944325-18-2(Hazardous Substances Data)

Upstream product

• 944324-94-1 (+/-)-1-cyano-1-cyclopentyl-1-phenylmethyl hydroxyacetate 
• 105-54-4 butanoic acid ethyl ester 
• 110-38-3 decanoic acid ethyl ester 
• 4704-31-8 vinyl caprate 
• 2146-71-6 vinyl laurate 
• 769-78-8 vinyl benzoate 

Downstream Products

• 64471-43-8 (S)-α-cyclopentyl-α-hydroxy-α-phenylacetic acid 

Relevant articles and documents

Enzymatic resolution of hindered cyanohydrins, key precursors of muscarinic receptor antagonists

Enantiomerically pure 1-cycloalkyl-1-hydroxy-1-phenylcyanohydrins, key precursors in the synthesis of (S)-oxybutynin and other antimuscarinic agents, have been successfully prepared via lipase-catalyzed kinetic resolutions. Pseudomonas cepacia and Candida antarctica lipase B have shown excellent enantioselectivities in hydrolysis and acylation processes, depending on the substrate structure and the reaction conditions. Furthermore, molecular modeling of phosphonate transition state analogue for the C. antarctica lipase B enzymatic hydrolysis resolution step supports these facts, which were experimentally observed.