944351-48-8

Basic information

• Product Name: (6-Fluoronaphthalen-2-yl)methanol
• Synonyms: (6-Fluoronaphthalen-2-yl)methanol
• CAS NO: 944351-48-8
• Molecular Formula: C11H9FO
• Molecular Weight: 176.19
• Mol File: 944351-48-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 102 - 103 °C
• CAS DataBase Reference: (6-Fluoronaphthalen-2-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (6-Fluoronaphthalen-2-yl)methanol(944351-48-8)
• EPA Substance Registry System: (6-Fluoronaphthalen-2-yl)methanol(944351-48-8)

Safety Data

• Hazardous Substances Data: 944351-48-8(Hazardous Substances Data)

Upstream product

• 721968-77-0 6-fluoro-2-naphthaldehyde 
• 324-41-4 2-bromo-6-fluoronaphthalene 
• 5043-01-6 6-fluoro-2-naphthoic acid 

Downstream Products

• 721968-77-0 6-fluoro-2-naphthaldehyde 
• 1439362-04-5 tert-butyl 3-((4-((N-((6-fluoronaphthalen-2-yl)methyl)-2-nitrophenylsulfonamido)methyl)benzyl)(naphthalen-1-ylmethyl)amino)propylcarbamate 
• 581-72-6 2-bromomethyl-6-fluoronaphthalene 

Relevant articles and documents

BICYCLIC CARBOXAMIDES AND METHODS OF USE THEREOF

Compounds, compositions and methods are provided for modulating the activity of EP2 and EP4 receptors, and for the treatment, prevention and amelioration of one or more symptoms of diseases or disorders related to the activity of EP2 and EP4 receptors. In certain embodiments, the compounds are antagonists of both the EP2 and EP4 receptors.

Single-step syntheses of no-carrier-added functionalized [ 18F]fluoroarenes as labeling synthons from diaryliodonium salts

Radiotracers labelled with short-lived fluorine-18 (t1/2 = 109.7 min) are keenly sought for biomedical imaging with positron emission tomography (PET). The radiotracers are mostly required at high specific radioactivities, necessitating their radiosyntheses from cyclotron-produced no-carrier-added [18F]fluoride ion. PET radiotracers encompass wide structural diversity and molecular weight. Hence, diverse 18F-labeling methodology is needed to accomplish the required radiosyntheses in a simple and rapid manner. A useful strategy is to introduce nucleophilic [ 18F]fluoride ion first into a labeling synthon that may then be applied to label the target radiotracer. Here, we show that various functionalized [18F]fluoroarenes may be rapidly synthesized as labeling synthons through single-step reactions of appropriate diaryliodonium salts with [18F]fluoride ion. Decay-corrected radiochemical yields (RCYs) varied with position of functional group, choice of electron-rich aryl ring in the diaryliodonium salt, and choice of anion. Under best conditions, 18F-labeled fluorobenzaldehydes, fluorobenzyl halides, fluorobenzoic acid esters and fluorophenyl ketones were obtained selectively in 40-73%, 20-55%, 46-89% and 81-98% RCYs, respectively. This versatile straightforward methodology will enhance the scope for producing structurally complex, yet useful, PET radiotracers.