94445-81-5

Basic information

• Product Name: 1,2,4-Triazolo[3,4-a]phthalazine, 3-(4-chlorophenyl)-
• CAS NO: 94445-81-5
• Molecular Formula: C15H9ClN4
• Molecular Weight: 280.716
• Mol File: 94445-81-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1,2,4-Triazolo[3,4-a]phthalazine, 3-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Triazolo[3,4-a]phthalazine, 3-(4-chlorophenyl)-(94445-81-5)
• EPA Substance Registry System: 1,2,4-Triazolo[3,4-a]phthalazine, 3-(4-chlorophenyl)-(94445-81-5)

Safety Data

• Hazardous Substances Data: 94445-81-5(Hazardous Substances Data)

Upstream product

• 1044569-46-1 1-hydrazinophthalazine 
• 104-88-1 4-chlorobenzaldehyde 
• 304-20-1 hydralazine hydrochloride 
• 97142-38-6 N-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-N'-phthalazin-1-yl-hydrazine 
• 94445-85-9 C₂₂H₁₆Cl₂N₄O₂ 
• 536-40-3 4-chlorobenzoic acid hydrazide 

Downstream Products

• 104615-50-1 2-[5-(4-Chloro-phenyl)-2H-[1,2,4]triazol-3-yl]-benzamide 
• 104615-51-2 3-(4-chlorophenyl)-5-(2-cyanophenyl)-1H-1,2,4-triazole 

Relevant articles and documents

Potential antibacterial agents: Part VI- synthesis and structure elucidation of Schiff bases derived from hydralazine

Synthesis of hydrazones (Schiff bases) of an antihypertensive drug, hydralazine was carried out. The study afforded the hitherto unreported l-[4-chlorobenzylidene]-hydrazinophthalazine (III-a), l-[benzylidene]- hydrazinophthalazine (III-b), l-[4-nitrobenzylidene]-hydrazinophthalazine (III-c), l-[2-nitrobenzylidene]-hydrazinophthalazine (III-d), 3-[4-chlorophenyl]-s-triazolo [3-4-a] phthalazine (IV-a) and 3-phenyl-s-triazolo [3-4-a] phthalazine (IV-b). The structures of these compounds were established using spectroscopic techniques i.e. IR, UV, 1HNMR, EIMS, FD and HRMS. Antibacterial activity of the drugs was evaluated.

Triazoloquinazoline compounds, and their methods of preparation, pharmaceutical compositions, and uses

[1,2,4]triazolo[1,5-c]quinazoline compounds of the formula STR1 wherein R1 is optionally substituted phenyl, pyridyl, furyl thienyl, dihydro or tetrahydro furanyl or thienyl, pyranyl, or 0-ribofuranosyl; R2 is hydrogen or lower alkyl; X is oxygen or NR3, R3 is as defined in the claims, and ring A is unsubstituted or substituted as set forth in the claims. The compounds wherein X is N--R3 are especially useful as adenosine antagonists and for the treatment of asthma. The compounds wherein X is oxygen are useful as benzodiazepine antagonists and as intermediates in the synthesis of the compounds wherein X is N--R3.