94451-06-6

Basic information

• Product Name: 2H-Pyran-2-one, 5,6-dihydro-3-(phenylthio)-
• CAS NO: 94451-06-6
• Molecular Formula: C11H10O2S
• Molecular Weight: 206.265
• Mol File: 94451-06-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2H-Pyran-2-one, 5,6-dihydro-3-(phenylthio)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Pyran-2-one, 5,6-dihydro-3-(phenylthio)-(94451-06-6)
• EPA Substance Registry System: 2H-Pyran-2-one, 5,6-dihydro-3-(phenylthio)-(94451-06-6)

Safety Data

• Hazardous Substances Data: 94451-06-6(Hazardous Substances Data)

Upstream product

• 542-28-9 3,4,5,6-tetrahydro-2H-pyran-2-one 
• 931-59-9 benzenesulfenyl chloride 
• 882-33-7 diphenyldisulfane 
• 100591-69-3 3-Benzenesulfinyl-tetrahydro-pyran-2-one 
• 89036-08-8 2-(phenylthio)-5-pentanolide 

Downstream Products

• 94450-93-8 (3R,4R)-4-(3,5-Dimethyl-4-methylene-cyclohexa-2,5-dienyl)-3-phenylsulfanyl-tetrahydro-pyran-2-one 
• 94451-09-9 (3S,4R)-4-(2,6-Dimethyl-benzyl)-3-phenylsulfanyl-tetrahydro-pyran-2-one 
• 89030-22-8 3-Methyl-2-phenylthio-5-pentanolide 
• 89030-24-0 2-Phenylthio-3-vinyl-5-pentanolide 
• 94450-90-5 3-Benzyl-2-phenylthio-5-pentanolide 
• 89030-25-1 3--2-phenylthio-5-pentanolide 
• 94451-12-4 3-Benzenesulfinyl-4-(2,6-dimethyl-benzyl)-3-methyl-tetrahydro-pyran-2-one 
• 94450-95-0 2-Phenylthio-3-(3,4,5-trimethylphenyl)-5-pentanolide 
• 94451-10-2 3-(2,6-Dimethylbenzyl)-2-methyl-2-phenylthio-5-pentanolide 
• 135253-20-2 3-Butyl-3-methyl-2-phenylthio-5-pentanolide 
• 94450-89-2 3-(2,6-Dimethylbenzyl)-2-methyl-2-penten-5-olide 
• 135253-19-9 3,3-Dimethyl-2-phenylthio-5-pentanolide 
• 94482-84-5 (+/-)-secocrispiolide (2-methylene-3-(2,6-dimethylbenzyl)-5-pentanolide) 
• 1121-84-2 4-methyl-tetrahydro-pyran-2-one 

Relevant articles and documents

An Useful Synthetic Method for 3-Substituted δ-Lactones. Synthesis of (+/-)-Secocrispiolide

2-Phenylthio-2-penten-5-olide (1) acted as a reactive Michael acceptor toward some typical carbon nucleophiles to give 3-substituted 2-phenylthio-5-pentanolides (2) which were convertible both to 3-substituted 5-pentanolides by reductive desulfurization and to 3-substituted 2-penten-5-olides by sulfenic acid syn elimination of the sulfoxides 4 derived from 2.The Pummerer rearrangement of 4 provided 3-substituted 2-phenylthio-2-penten-5-olides and/or 2-hydroxy-2-penten-5-olides. (+/-)-Secocrispiolide was synthesized via the adduct obtained by the Michael reaction of 1 with the Grignard reagent prepared from 2,6-dimethylbenzyl bromide and magnesium.