944718-22-3

Basic information

• Product Name: 1-(5-broMopyridin-2-yl)cyclopropanaMine
• Synonyms: 1-(5-broMopyridin-2-yl)cyclopropanaMine
• CAS NO: 944718-22-3
• Molecular Formula: C8H9BrN2
• Molecular Weight: 213.07446
• Mol File: 944718-22-3.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(5-broMopyridin-2-yl)cyclopropanaMine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-broMopyridin-2-yl)cyclopropanaMine(944718-22-3)
• EPA Substance Registry System: 1-(5-broMopyridin-2-yl)cyclopropanaMine(944718-22-3)

Safety Data

• Hazardous Substances Data: 944718-22-3(Hazardous Substances Data)

Usage

General Description

1-(5-bromopyridin-2-yl)cyclopropanamine is a chemical compound with the molecular formula C8H10BrN. It is a cyclopropanamine derivative containing a bromopyridine group. 1-(5-broMopyridin-2-yl)cyclopropanaMine is used in medicinal chemistry and drug discovery as a building block for the synthesis of various biologically active molecules. The cyclopropanamine moiety in the compound can confer unique properties to the molecules it is incorporated into, making it a valuable tool for the development of novel pharmaceuticals and chemical probes. The bromopyridine group also provides potential for further functionalization and diversification of the compound, enhancing its utility in synthetic chemistry.

Upstream product

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Relevant articles and documents

SULFONAMIDE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG

The present invention relates to Sulfonamide Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, W, X, R1, R2, R3, R4 and R5 are as defined herein. The present invention also relates to compositions comprising at least one Sulfonamide Derivative, and methods of using the Sulfonamide Derivatives for improving the pharmacokinetics of a drug.

SULFONAMIDE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG

The present invention relates to Sulfonamide Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, W, X, R1, R2, R3, R4 and R5 are as defined herein. The present invention also relates to compositions comprising at least one Sulfonamide Derivative, and methods of using the Sulfonamide Derivatives for improving the pharmacokinetics of a drug.

PYRIDINE AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS

The invention relates pyridine amide derivative of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are independently hydrogen, linear o branched (C1-C3)alkyl or joined together they form a cyclopropyl ring; R is independently selected from the group consisting of halogens and trifluoromethyl and p is 1, 2 or 3; A is C or N; E is a group of formula (B) or (C), wherein B is C(O)OH, C(O)O(C1-C3)alkyl, and C is selected from the group consisting of formula (I) m is 1,2 or 3, n is 0 or 1, W is —O—, —O(C1-C3 alkyl)-; —(C1-C3 alkyl)O—; —C(O)—; —C(═N—O(C1-C3 alkyl))-; —NH— or —NH(C1-C3alkyl)-; Ar is phenyl, optionally substituted with one or more substituents selected from the group consisting of halogen, trifluoromethyl, trifluoromethoxy, methyl, —NH(C1-C3alkyl)-; —N(C1-C3alkyl)(C1-C3alkyl)-, a from 5 to 7 membered heterocyclic ring containing one nitrogen atom which is covalently bonded to Ar and optionally containing one or two heteroatoms selected from N, O and S; and a 5- or 6-membered heteroaromatic ring containing 1 to 3 heteroatoms selected from S, O e N, such heteroaromatic ring being substituted with one or two substituents selected from the group consisting of (C1-C3)alkyl, (C3-C5)cycloalkyloxy, (C1-C3)alkylcarbonyl. The compounds of the invention could be used for manufacturing a medicament for the treatment of pathologies which require the use of an antagonist of the EP4 receptor, such as the treatment of acute and chronic pain, inflammatory pain, osteoarthritis, inflammation-associated disorder as arthritis, rheumatoid arthritis, cancer, endometriosis and migraine.