94483-00-8

Basic information

• Product Name: Hexadecanoic acid, 1-(3-hydroxy-3-oxido-8,8,8-triphenyl-2,4-dioxa-7-aza-3-phosphaoct-1-yl )-1,2-ethanediyl ester
• CAS NO: 94483-00-8
• Molecular Formula: C56H88NO8P
• Molecular Weight: 934.29
• Mol File: 94483-00-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Hexadecanoic acid, 1-(3-hydroxy-3-oxido-8,8,8-triphenyl-2,4-dioxa-7-aza-3-phosphaoct-1-yl )-1,2-ethanediyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Hexadecanoic acid, 1-(3-hydroxy-3-oxido-8,8,8-triphenyl-2,4-dioxa-7-aza-3-phosphaoct-1-yl )-1,2-ethanediyl ester(94483-00-8)
• EPA Substance Registry System: Hexadecanoic acid, 1-(3-hydroxy-3-oxido-8,8,8-triphenyl-2,4-dioxa-7-aza-3-phosphaoct-1-yl )-1,2-ethanediyl ester(94483-00-8)

Safety Data

• Hazardous Substances Data: 94483-00-8(Hazardous Substances Data)

Upstream product

• 5681-36-7 1,2-dipalmitoyl-sn-glycero-3-phospoethanolamine 
• 76-83-5 trityl chloride 
• 596-43-0 bromo-triphenyl-methane 

Downstream Products

• 94451-78-2 Hexadecanoic acid 2-{[2-(4-bromo-phenyl)-2-oxo-ethoxy]-[2-(3-{(S)-1-carboxy-2-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]-ethylcarbamoyl}-propionylamino)-ethoxy]-phosphoryloxy}-1-hexadecanoyloxymethyl-ethyl ester 
• 94451-75-9 (2R,4S)-2-[(R)-(2-{(2,3-Bis-hexadecanoyloxy-propoxy)-[2-(4-nitro-phenyl)-ethoxy]-phosphoryloxy}-ethylcarbamoyl)-phenylacetylamino-methyl]-5,5-dimethyl-thiazolidine-4-carboxylic acid 2-(4-bromo-phenyl)-2-oxo-ethyl ester 
• 94451-74-8 (2R,4S)-2-[(R)-(2-{(2,3-Bis-hexadecanoyloxy-propoxy)-[2-(4-bromo-phenyl)-2-oxo-ethoxy]-phosphoryloxy}-ethylcarbamoyl)-phenylacetylamino-methyl]-5,5-dimethyl-thiazolidine-4-carboxylic acid 2-(4-bromo-phenyl)-2-oxo-ethyl ester 
• 94491-16-4 Hexadecanoic acid 2-{[2-(3-{(S)-1-carboxy-2-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]-ethylcarbamoyl}-propionylamino)-ethoxy]-hydroxy-phosphoryloxy}-1-hexadecanoyloxymethyl-ethyl ester 
• 94451-76-0 (2R,4S)-2-((R)-{2-[(2,3-Bis-hexadecanoyloxy-propoxy)-hydroxy-phosphoryloxy]-ethylcarbamoyl}-phenylacetylamino-methyl)-5,5-dimethyl-thiazolidine-4-carboxylic acid 
• 94451-77-1 Hexadecanoic acid 2-{[2-(4-bromo-phenyl)-2-oxo-ethoxy]-[2-(3-carboxy-propionylamino)-ethoxy]-phosphoryloxy}-1-hexadecanoyloxymethyl-ethyl ester 
• 94451-73-7 Hexadecanoic acid 2-{(2-amino-ethoxy)-[2-(4-nitro-phenyl)-ethoxy]-phosphoryloxy}-1-hexadecanoyloxymethyl-ethyl ester 
• 94451-70-4 Hexadecanoic acid 2-{(2-amino-ethoxy)-[2-(4-bromo-phenyl)-2-oxo-ethoxy]-phosphoryloxy}-1-hexadecanoyloxymethyl-ethyl ester 
• 94451-72-6 Hexadecanoic acid 2-{[2-(4-bromo-phenyl)-2-oxo-ethoxy]-[2-(trityl-amino)-ethoxy]-phosphoryloxy}-1-hexadecanoyloxymethyl-ethyl ester 
• 94451-71-5 Hexadecanoic acid 1-hexadecanoyloxymethyl-2-{[2-(4-nitro-phenyl)-ethoxy]-[2-(trityl-amino)-ethoxy]-phosphoryloxy}-ethyl ester 

Relevant articles and documents

Rapid tin-mediated access to a lysophosphatidylethanolamine (LPE) library: Application to positional LC/MS analysis for hepatic LPEs in non-alcoholic steatohepatitis model mice

Even though lysophospholipids have attracted much interest in recent years on account of their unique bioactivity, research related to lysophospholipids is usually hampered by problems associated with standard sample preparation and discrimination of regioisomers. Herein, we demonstrate a quick tin-chemistry-based synthetic route to lysophosphatidylethanolamines (LPEs) and its application in the positional analysis of hepatic LPEs in non-alcoholic steatohepatitis (NASH) model mice. We found that the preference of hepatic LPE regioisomer largely depends on the unsaturation of acyl chain in both control and NASH model mice. In addition, hepatic C18:2-LPE and C20:5-LPE levels were significantly lower in the NASH model mice than those in the control. The LC/MS technique based on the library of LPE regioisomers allows an accurate observation of hepatic LPE metabolism and might provide useful information to elucidate yet ambiguous pathogenesis of NASH.