944900-76-9 Usage
General Description
4-Methoxy-5-azaindole is a chemical compound with the molecular formula C8H8N2O. It is a synthetic heterocyclic compound with a methoxy group and an azaindole ring. 4-METHOXY-5-AZAINDOLE is primarily used as a building block in the synthesis of pharmaceuticals and agrochemicals. It has potential applications in drug discovery and development, particularly in the synthesis of new and diverse chemical entities for pharmaceutical research. The unique structure and properties of 4-methoxy-5-azaindole make it a valuable tool in medicinal and agricultural chemistry, with potential for the development of novel therapeutics and crop protection agents.
Check Digit Verification of cas no
The CAS Registry Mumber 944900-76-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,4,9,0 and 0 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 944900-76:
(8*9)+(7*4)+(6*4)+(5*9)+(4*0)+(3*0)+(2*7)+(1*6)=189
189 % 10 = 9
So 944900-76-9 is a valid CAS Registry Number.
InChI:InChI=1/C8H8N2O/c1-11-8-6-2-4-9-7(6)3-5-10-8/h2-5,9H,1H3
944900-76-9Relevant articles and documents
A Journey through Hemetsberger–Knittel, Leimgruber–Batcho and Bartoli Reactions: Access to Several Hydroxy 5- and 6-Azaindoles
Radix, Sylvie,Hallé, Fran?ois,Mahiout, Zahia,Teissonnière, Amélie,Bouchez, Grégoire,Auberger, Ludovic,Barret, Roland,Lomberget, Thierry
, (2022/02/22)
The preparation of various 5- and 6-azaindoles, heterocyclic structures that are frequently part of molecules in clinical development, and their monohydroxy analogues were described. Different strategies, relying on the de novo pyrrole ring formation, were investigated and, thanks to Hemetsberger–Knittel, Bartoli and Leimgruber–Batcho approaches, 4- and 7-monohydroxy 5- and 6-azaindoles were obtained. The crucial introduction of the oxygen atom was carried out from halogen derivatives, using nucleophilic substitution reactions under basic conditions with or without a copper catalyst. Some preliminary oxidation reactions have shown that it was yet not possible to synthesize the azaquinone indole structure from monohydroxy azaindole, using molecular oxygen in the presence of salcomine as a catalyst.