944916-43-2

Basic information

• Product Name: 4-(4-(trifluoromethyl)phenyl)-1H-imidazol-2(3H)-one
• Synonyms: 4-(4-(trifluoromethyl)phenyl)-1H-imidazol-2(3H)-one
• CAS NO: 944916-43-2
• Molecular Weight: 228.174
• Mol File: 944916-43-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(4-(trifluoromethyl)phenyl)-1H-imidazol-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-(trifluoromethyl)phenyl)-1H-imidazol-2(3H)-one(944916-43-2)
• EPA Substance Registry System: 4-(4-(trifluoromethyl)phenyl)-1H-imidazol-2(3H)-one(944916-43-2)

Safety Data

• Hazardous Substances Data: 944916-43-2(Hazardous Substances Data)

Upstream product

• 590-28-3 potassium cyanate 
• 339-58-2 2-amino-1-[4-(trifluoromethyl)phenyl]-1-ethanone hydrogen chloride 
• 5918-93-4 1,3-dihydroimidazolone 
• 402-43-7 p-trifluoromethylphenyl bromide 

Relevant articles and documents

Structure-activity relationship (SAR) investigations of substituted imidazole analogs as TRPV1 antagonists

A novel series of 4,5-biarylimidazoles as TRPV1 antagonists were designed based on the previously reported 4,6-disubstituted benzimidazole series. The analogs were evaluated for their ability to block capsaicin- or acid-induced calcium influx in TRPV1-expressing CHO cells. These studies led to the identification of a highly potent and orally bioavailable TRPV1 antagonist, imidazole 33.