94512-73-9

Basic information

• Product Name: 2-BROMO-1-(4''-BROMO-1,1''-BIPHENYL-4-YL)ETHANONE
• Synonyms: 1-(BroMoacetyl)-4-(4-broMophenyl)benzene;2-bromo-1-(4'-bromo-biphenyl-4-yl)-ethanone
• CAS NO: 94512-73-9
• Molecular Formula: C₁₄H₁₀Br₂O
• Molecular Weight: 354.04
• Mol File: 94512-73-9.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 413.5°Cat760mmHg
• Flash Point: 118.6°C
• Appearance: /
• Density: 1.642g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-BROMO-1-(4''-BROMO-1,1''-BIPHENYL-4-YL)ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-1-(4''-BROMO-1,1''-BIPHENYL-4-YL)ETHANONE(94512-73-9)
• EPA Substance Registry System: 2-BROMO-1-(4''-BROMO-1,1''-BIPHENYL-4-YL)ETHANONE(94512-73-9)

Safety Data

• Hazardous Substances Data: 94512-73-9(Hazardous Substances Data)

Usage

General Description

2-BROMO-1-(4''-BROMO-1,1''-BIPHENYL-4-YL)ETHANONE is a compound that belongs to the family of ketones and contains two bromine atoms. Its molecular formula is C14H10Br2O, and it has a molecular weight of 349.04 g/mol. This chemical is a yellow solid with a melting point of around 54-58°C. It is commonly used in organic synthesis and as an intermediate in the production of pharmaceuticals and agrochemicals. The presence of bromine atoms in the compound makes it reactive and suitable for various chemical reactions and transformations in the laboratory.

Upstream product

• 5731-01-1 4-bromo-4'-acetylbiphenyl 
• 92-66-0 4-bromo-1,1'-biphenyl 

Downstream Products

• 1061457-00-8 2-[4-(4-bromophenyl)phenyl]-4-methylmorpholin-2-ol 
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• 1335316-41-0 2-[2-[4-(4-bromophenyl)phenyl]-2-oxo-ethyl]-1-tert-butyl-(2S,5S)-5-methylpyrrolidine-1,2-dicarboxylate 
• 1335316-22-7 (2S,4S)-2-(2-(4'-bromobiphenyl-4-yl)-2-oxoethyl) 1-tert-butyl 4-methylpyrrolidine-1,2-dicarboxylate 

Relevant articles and documents

insecticide compositions, insecticidal products containing them and methods of eradicating pests using them

Styryltriazole compounds having activity as antiparasitic hormone antagonists. Provided are an insecticide composition comprising an isomer or a pharmaceutically acceptable salt thereof, an insecticide product comprising the same, and a method for combating pests using the same.

ANALOGUES FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS

Compounds represented by formula I as described herein or pharmaceutically acceptable salts thereof, wherein A, B, B', X, Y, R1, R2, R2', R3, R3', R4, R4', R5, R5', m, n, or p are as defined herein, are useful for treating flaviviridae viral infections.

Heme oxygenase inhibition by 1-Aryl-2-(1H-imidazol-1-yl/1H-1,2,4-triazol-1- yl)ethanones and their derivatives

Previous studies by our research group have been concerned with the design of selective inhibitors of heme oxygenases (HO-1 and HO-2). The majority of these were based on a four-carbon linkage of an azole, usually an imidazole, and an aromatic moiety. In the present study, we designed and synthesized a series of inhibition candidates containing a shorter linkage between these groups, specifically, a series of 1-aryl-2-(1H-imidazol-1-yl/1H-1,2,4-triazol-1-yl) ethanones and their derivatives. As regards HO-1 inhibition, the aromatic moieties yielding best results were found to be halogen-substituted residues such as 3-bromophenyl, 4-bromophenyl, and 3,4-dichlorophenyl, or hydrocarbon residues such as 2-naphthyl, 4-biphenyl, 4-benzylphenyl, and 4-(2-phenethyl)phenyl. Among the imidazole-ketones, five (36-39, and 44) were found to be very potent (IC5050 in favor of HO-1. In the case of the azole-dioxolanes, two of them (80 and 85), each possessing a 2-naphthyl moiety, were found to be particularly potent and selective HO-1 inhibitors. Three non-carbonyl analogues (87, 89, and 91) of 1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)ethanone were found to be good inhibitors of HO-1. For the first time in our studies, two azole-based inhibitors (37 and 39) were found to exhibit a modest selectivity index in favor of HO-2. The present study has revealed additional candidates based on inhibition of heme oxygenases for potentially useful pharmacological and therapeutic applications.