945224-75-9

Basic information

• Product Name: C₂₃H₁₉F₃N₄O₄
• CAS NO: 945224-75-9
• Molecular Weight: 472.423
• Mol File: 945224-75-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₁₉F₃N₄O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₁₉F₃N₄O₄(945224-75-9)
• EPA Substance Registry System: C₂₃H₁₉F₃N₄O₄(945224-75-9)

Safety Data

• Hazardous Substances Data: 945224-75-9(Hazardous Substances Data)

Upstream product

• 86439-16-9 3-trifluoromethyl-5-phenyl-2,6-dicyanoaniline 
• 853052-83-2 3-iodo-5-(trifluoromethyl)biphenyl-2,4-dicarbonitrile 
• 945224-59-9 3-amino-4-trifluoromethyl-6-phenylindazole 
• 18856-68-3 diethyl N,N-dimethylaminomethylenemalonate 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 

Relevant articles and documents

Synthesis and structure-activity relationships of novel pyrimido[1,2-b]indazoles as potential anticancer agents against A-549 cell lines

A series of novel pyrimido[1,2-b]indazoles 5, 7 have been prepared from 3-trifluoromethyl-5-phenyl-2,6-dicyano anilines 1 via novel indazole regioisomers 3 and 4 through a facile strategy. Specific examples were evaluated for anticancer activity in vitro and found to exhibit promising activity against A-549 cell lines and are more effective than Etoposide. QSAR models were developed and validated by cross-validation method. The results of the best QSAR model were further compared with the crystal structure of tubulin protein. The binding energies estimated were found to have a good correlation with the experimental inhibitory potencies.