94535-01-0

Basic information

• Product Name: Halleridone
• Synonyms: Halleridone;3,3a,7,7a-Tetrahydro-3a-hydroxybenzofuran-6(2H)-one;3a-Hydroxy-2,3,3a,7a-tetrahydro-6(7H)-benzofuranone
• CAS NO: 94535-01-0
• Molecular Formula: C₈H₁₀O₃
• Molecular Weight: 154.16
• Mol File: 94535-01-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 332.9°Cat760mmHg
• Flash Point: 142.6°C
• Appearance: /
• Density: 1.361g/cm³
• Vapor Pressure: 1.01E-05mmHg at 25°C
• Refractive Index: 1.581
• CAS DataBase Reference: Halleridone(CAS DataBase Reference)
• NIST Chemistry Reference: Halleridone(94535-01-0)
• EPA Substance Registry System: Halleridone(94535-01-0)

Safety Data

• Hazardous Substances Data: 94535-01-0(Hazardous Substances Data)

Usage

General Description

Halleridone, also known as 2-(3,4-dimethylphenyl)-7-hydroxy-4H-chromen-4-one, is a chemical compound that belongs to the class of flavonoids. It is a natural product found in plants such as Halleria lucida and has been studied for its potential pharmacological properties, including antioxidant and anti-inflammatory effects. Halleridone has also been investigated for its potential use in the treatment of various diseases, such as cancer and neurodegenerative disorders. Further research is needed to fully understand the therapeutic potential of halleridone and its mechanisms of action.

InChI:InChI=1/C8H10O3/c9-6-1-2-8(10)3-4-11-7(8)5-6/h1-2,7,10H,3-5H2

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Relevant articles and documents

Total synthesis of incargranine A

Synthetic studies into the origins of the alkaloid incargranine A have resulted in the development of a four-step (longest linear sequence) total synthesis. This synthesis has been scaled-up to provide gram-scale quantities of material, which would alternatively require extraction of several metric-tons of dried-whole Chinese Trumpet-Creeper plants (Incarvillea mairei var. grandiflora).

Tandem sequence of phenol oxidation and intramolecular addition as a method in building heterocycles

A tandem phenol oxidation-Michael addition furnishing oxo- and -aza-heterocycles has been developed. Dirhodium caprolactamate [Rh 2(cap)4] catalyzed oxidation by T-HYDRO of phenols with alcohols, ketones, amides, carboxylic acids, and N-Boc protected amines tethered to their 4-position afforded 4-(tert-butylperoxy)cyclohexa-2,5-dienones that undergo Bronsted acid catalyzed intramolecular Michael addition in one-pot to produce oxo- and -aza-heterocycles in moderate to good yields. The scope of the developed methodology includes dipeptides Boc-Tyr-Gly-OEt and Boc-Tyr-Phe-Me and provides a pathway for understanding the possible transformations arising from oxidative stress of tyrosine residues. A novel method of selective cleavage of O-O bond in hindered internal peroxide using TiCl4 has been discovered in efforts directed to the construction of cleroindicin F, whose synthesis was completed in 50% yield over just 3 steps from tyrosol using the developed methodology.

Oxidative de-aromatization of para-alkyl phenols into para-peroxyquinols and para-quinols mediated by oxone as a source of singlet oxygen

(Chemical Equation Presented) Easy does it: Easily handled and environmentally safe oxone generates singlet oxygen which effects the simple and selective oxidative de-aromatization of para-alkyl phenols 1 into para-peroxyquinols 2 under very mild conditions with good to excellent yields. A one-pot access to para-quinols 3 from 1 is also possible after treatment of the crude reaction mixture with sodium thiosulfate.