945368-81-0Relevant articles and documents
Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools
Blundell, Tom L.,Botros, Sanaa S.,Campillo, Nuria E.,El-Lakkany, Naglaa M.,García-Rubia, Alfonso,Gil, Carmen,Maes, Louis,Martinez, Ana,Sabra, Abdel-Nasser A.,Sebastian-Perez, Victor,Seif el-Din, Sayed H.,William, Samia
, p. 511 - 523 (2020)
A previous phenotypic screening campaign led to the identification of a quinazoline derivative with promising in vitro activity against Schistosoma mansoni. Follow-up studies of the antischistosomal potential of this candidate are presented here. The in v
Aldose reductase inhibition by 2,4-oxo and thioxo derivatives of 1,2,3,4-tetrahydroquinazoline
Billon, Florence,Delchambre, Chantal,Cloarec, Alix,Sartori, Eric,Teulon, Jean-Marie
, p. 121 - 126 (2007/10/02)
Inhibitors of aldose reductase are believed to be useful for the treatment of diabetic complications.Original acetic acids and their thioxo derivatives have been synthesized and examined for their ability to inhibit aldose reductase in vitro and in vivo.Most were active in vitro on rat lens aldose reductase in the 10-7 molar range.Compound V16, which has a (2'-fluoro-4'-bromo)benzyl substituent on nitrogen N-3 was found in hypergalactosemic rats to be a good inhibitor of galactitol accumulation in sciatic nerves andto prevent cataract formation.