94567-78-9

Basic information

• Product Name: Methyl 3,4-dihydroquinoline-1(2H)-carboxylate
• Synonyms: Methyl 3,4-dihydroquinoline-1(2H)-carboxylate;3,4-Dihydro-2H-quinoline-1-carboxylic acid methyl ester
• CAS NO: 94567-78-9
• Molecular Formula: C11H13NO2
• Molecular Weight: 191.22642
• Mol File: 94567-78-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Methyl 3,4-dihydroquinoline-1(2H)-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3,4-dihydroquinoline-1(2H)-carboxylate(94567-78-9)
• EPA Substance Registry System: Methyl 3,4-dihydroquinoline-1(2H)-carboxylate(94567-78-9)

Safety Data

• Hazardous Substances Data: 94567-78-9(Hazardous Substances Data)

Upstream product

• 79-22-1 methyl chloroformate 
• 767-92-0 decahydroquinoline 
• 13240-36-3 quinoline-N-borane 
• 51483-72-8 4H-quinoline-1-carboxylic acid methyl ester 
• 635-46-1 1,2,3,4-tetrahydroisoquinoline 

Downstream Products

• 139525-70-5 methyl 6-bromo-3,4-dihydroquinoline-1(2H)-carboxylate 
• 1206965-53-8 tert-butyl (2-oxo-8-phenyl-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-1(2H)-yl)acetate 
• 863724-39-4 (2-oxo-8-phenyl-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-1(2H)-yl)acetic acid 

Relevant articles and documents

Gold-catalyzed hydroarylation of allenes: A highly regioselective carbon-carbon bond formation producing six-membered rings

(Chemical Equation Presented) Gold-catalyzed intramolecular hydroarylation of allenic anilines and phenols offers an efficient route to dihydroquinoline and chromene derivatives under mild reaction conditions. The hydroarylation takes place at the terminal or central allenic carbon depending on the substrate structure, leading to a highly selective formation of six-membered rings.

AMINO PYRIMIDINE COMPOUND FOR INHIBITING PROTEIN TYROSINE KINASE ACTIVITY

An amino pyrimidine compound for inhibiting protein tyrosine kinase activity, a pharmaceutical composition thereof, preparation therefor, and an application thereof. Specifically, an amino pyrimidine compound represented by formula (I), R1, R2, L, Y, R6, W, A, m, and n being defined in the specification, and a pharmaceutically acceptable salt, a stereoisomer, a solvent compound, a hydrate, a polymorphism, a prodrug, or an isotope variant thereof. The compound can be used for treating and/or preventing protein tyrosine kinase-related diseases such as cell proliferative diseases, cancers, and immune diseases.

Synthesis of diverse 2,3-dihydroindoles, 1,2,3,4-tetrahydroquinolines, and benzo-fused azepines by formal radical cyclization onto aromatic rings

(Chemical Equation Presented) 2,3-Dihydroindoles, 1,2,3,4- tetrahydroquinolines, and 2,3,4,5-tetrahydrobenzo[b]azepines are available by a process that represents formal radical cyclization onto aromatic rings. Optically pure benzo-fused heterocycles are also accessible by this method. p-Iodophenols, especially those with the phenolic oxygen protected as a MOM-ether, can be coupled with amino alcohols to produce N-aryl amino alcohols, which can be converted into the corresponding alkyl iodides in which the nitrogen is protected as a carbamate. These compounds give cross-conjugated ketones after removal of the phenolic protecting group and oxidation with PhI(OAc)2 in the presence of MeOH. The ketones undergo 5-, 6- or 7-exo-trigonal radical cyclization, and then exposure to acid, or sequential treatment with a Grignard reagent and then acid, effects rearomatization to produce the benzo-fused nitrogen heterocycles.