945724-02-7

Basic information

• Product Name: (E)-1-(4-bromo-2-hydroxyphenyl)-3-(dimethylamino)prop-2-en-1-one
• Synonyms: (E)-1-(4-bromo-2-hydroxyphenyl)-3-(dimethylamino)prop-2-en-1-one
• CAS NO: 945724-02-7
• Molecular Weight: 270.126
• Mol File: 945724-02-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (E)-1-(4-bromo-2-hydroxyphenyl)-3-(dimethylamino)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-(4-bromo-2-hydroxyphenyl)-3-(dimethylamino)prop-2-en-1-one(945724-02-7)
• EPA Substance Registry System: (E)-1-(4-bromo-2-hydroxyphenyl)-3-(dimethylamino)prop-2-en-1-one(945724-02-7)

Safety Data

• Hazardous Substances Data: 945724-02-7(Hazardous Substances Data)

Usage

Description

(E)-1-(4-bromo-2-hydroxyphenyl)-3-(dimethylamino)prop-2-en-1-one is an organic compound characterized by its molecular formula C12H13BrNO2. It is a yellow crystalline powder that features a 4-bromo-2-hydroxyphenyl group and a dimethylamino group attached to a prop-2-en-1-one structure. (E)-1-(4-bromo-2-hydroxyphenyl)-3-(dimethylamino)prop-2-en-1-one is known for its versatile applications in the chemical, pharmaceutical, material science, and catalysis industries.

Uses

Used in Pharmaceutical Applications:
(E)-1-(4-bromo-2-hydroxyphenyl)-3-(dimethylamino)prop-2-en-1-one is used as a building block for the synthesis of various pharmaceuticals. Its unique structure allows for the creation of a wide range of compounds with potential therapeutic properties.
Used in Agrochemical Applications:
In the agrochemical industry, (E)-1-(4-bromo-2-hydroxyphenyl)-3-(dimethylamino)prop-2-en-1-one is utilized as a key component in the development of new agrochemicals, contributing to the advancement of crop protection and pest control solutions.
Used in Material Science:
(E)-1-(4-bromo-2-hydroxyphenyl)-3-(dimethylamino)prop-2-en-1-one is also employed in the field of material science, where it is explored for its potential to enhance the properties of various materials, such as improving their stability, reactivity, or other characteristics.
Used in Catalysis:
(E)-1-(4-bromo-2-hydroxyphenyl)-3-(dimethylamino)prop-2-en-1-one has potential applications in catalysis, where it may be used to improve the efficiency of chemical reactions or to facilitate the synthesis of other compounds.
Overall, (E)-1-(4-bromo-2-hydroxyphenyl)-3-(dimethylamino)prop-2-en-1-one is a valuable compound with a diverse range of applications across multiple industries, making it a subject of interest for researchers and developers.

Upstream product

• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 55736-69-1 1-(2-bromo-6-hydroxyphenyl)ethan-1-one 
• 30186-18-6 4'-bromo-2'-hydroxyacetophenone 
• 68-12-2 N,N-dimethyl-formamide 
• 288067-35-6 4-bromo-2-hydroxy-benzonitrile 
• 5815-08-7 tert-Butoxybis(dimethylamino)methane 

Downstream Products

• 1180671-95-7 (E,Z)-7-bromochroman-4-one O-tosyl oxime 
• 1180671-97-9 7-bromo-3-amino-chroman-4-one hydrochloride 
• 18442-22-3 7-Bromo-2,3-dihydro-4H-chromen-4-one 

Relevant articles and documents

Discovery of Chromane Containing Hepatitis C Virus (HCV) NS5A Inhibitors with Improved Potency against Resistance-Associated Variants

The discovery of potent and pan-genotypic HCV NS5A inhibitors faces many challenges including the significant diversity among genotypes, substantial potency shift conferred on some key resistance-associated variants, inconsistent SARs between different genotypes and mutants, and the lacking of models of inhibitor/protein complexes for rational inhibitor design. As part of ongoing efforts on HCV NS5A inhibition at Merck, we now describe the discovery of a novel series of chromane containing NS5A inhibitors. SAR studies around the "Z" group of the tetracyclic indole scaffold explored fused bicyclic rings as alternates to the phenyl group of elbasvir (1, MK-8742) and identified novel chromane and 2,3-dihydrobenzofuran derivatives as "Z" group replacements offered good potency across all genotypes. This effort, incorporating the C-1 fluoro substitution at the tetracyclic indole core, led to the discovery of a new series of NS5A inhibitors, such as compounds 14 and 25-28, with significantly improved potency against resistance-associated variants, such as GT2b, GT1a Y93H, and GT1a L31V. Compound 14 also showed reasonable PK exposures in preclinical species (rat and dog).

ANTIVIRAL COMPOUNDS

The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

CHROMANE ANTAGONIST OF THE H-3 RECEPTOR

This invention is directed to a compound of formula (I), as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula (I), a process of preparation of a compound of formula (I), a method of treatment of a disorder or condition that may be treated by antagonizing histamine H3 receptors, the method comprising administering to a mammal in need of such treatment a compound of formula (I) as described above, and a method of treatment of a disorder or condition selected from the group consisting of depression, mood disorders, schizophrenia, anxiety disorders, Alzheimer's disease, attention-deficit hyperactivity disorder (ADHD), psychotic disorders, cognitive disorders, sleep disorders, obesity, dizziness, epilepsy, motion sickness, respiratory diseases, allergy, allergy-induced airway responses, allergic rhinitis, nasal congestion, allergic congestion, congestion, hypotension, cardiovascular disease, diseases of the GI tract, hyper and hypo motility and acidic secretion of the gastro-intestinal tract, the method comprising administering to a mammal in need of such treatment a compound of formula (I) as described above.