945761-98-8 Usage
Molecular Weight
261.38 g/mol The molecular weight is the mass of one mole of the compound, calculated by adding the atomic weights of all the atoms in the molecule.
Structure
1H-Indazole, 7-[2-(trimethylsilyl)ethynyl]The structure refers to the specific arrangement of atoms in the molecule, which determines its chemical and physical properties.
Bicyclic Heterocycle
A bicyclic heterocycle is a cyclic compound containing two rings of atoms, one of which is a heteroatom (an atom other than carbon or hydrogen). In this case, the indazole ring is a bicyclic heterocycle consisting of a benzene ring fused to a five-membered nitrogen-containing pyrazole ring.
7-[2-(trimethylsilyl)ethynyl]Substitution
The substitution refers to the attachment of a trimethylsilyl-ethynyl group to the 7-position of the indazole ring. This modification can alter the chemical and physical properties of the compound.
Organic Synthesis
1H-Indazole, 7-[2-(trimethylsilyl)ethynyl]is commonly used in organic synthesis as a building block for the development of various drug candidates and bioactive molecules. It is a valuable tool in the synthesis of complex organic compounds due to its unique structure and reactivity.
Pharmaceutical Research
The compound is also used in pharmaceutical research as a building block for the development of drugs and other bioactive molecules. It can be used to create new compounds with potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 945761-98-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,5,7,6 and 1 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 945761-98:
(8*9)+(7*4)+(6*5)+(5*7)+(4*6)+(3*1)+(2*9)+(1*8)=218
218 % 10 = 8
So 945761-98-8 is a valid CAS Registry Number.
945761-98-8Relevant articles and documents
Highly Enantioselective Rhodium(I)-Catalyzed Alder-ene-type Cycloisomerization of 1,7-Enynes
Chen, Gen-Qiang,Fang, Wei,Lin, Bijin,Zeng, Jingwen,Zhang, Xumu
supporting information, p. 869 - 874 (2022/02/07)
The transition-metal-catalyzed asymmetric cycloisomerization of 1,7-enynes is regarded as a formidable challenge due to the poor ability of 1,7-enynes to serve as bidentate ligands to metal. In this Letter, a highly enantioselective rhodium(I)-catalyzed Alder-ene-type cycloisomerization of 1,7-enynes is disclosed, offering an efficient method for the synthesis of a wide range of fused six-membered cyclic compounds. Furthermore, a high turnover frequency experiment and deuterium-labeling experiment were performed to give insight into this transformation.
Efficient synthesis of 7-substituted or 3,7-disubstituted 1H-indazoles
Cottyn, Betty,Vichard, Dominique,Terrier, Fran?ois,Nioche, Pierre,Raman
, p. 1203 - 1206 (2008/01/08)
This work reports on the synthesis of the novel indazole scaffolds 7-OTf-1H-indazole (trifluoromethanesulfonic acid 1H-indazol-7-yl ester), 7-iodo-1H-indazole and 3-bromo-7-iodo-1H-indazole. These new compounds are potent building blocks in divergent syntheses of indazoles via palladium cross-coupling reactions. Georg Thieme Verlag Stuttgart.
