94581-94-9

Basic information

• Product Name: 7H-Pyrrolo[2,3-d]pyrimidine, 4-piperidino-
• CAS NO: 94581-94-9
• Molecular Weight: 202.259
• Mol File: 94581-94-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7H-Pyrrolo[2,3-d]pyrimidine, 4-piperidino- (CAS DataBase Reference)
• NIST Chemistry Reference: 7H-Pyrrolo[2,3-d]pyrimidine, 4-piperidino- (94581-94-9)
• EPA Substance Registry System: 7H-Pyrrolo[2,3-d]pyrimidine, 4-piperidino- (94581-94-9)

Safety Data

• Hazardous Substances Data: 94581-94-9(Hazardous Substances Data)

Upstream product

• 3680-71-5 7-deazahypoxanthine 

Relevant articles and documents

Rational design of 4,5-disubstituted-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-ones as a novel class of inhibitors of epidermal growth factor receptor (EGF-R) and Her2(p185(erbB)) tyrosine kinases.

A novel class of 4,5-disubstituted-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-ones has been discovered as potent and selective inhibitors of the EGF-R tyrosine kinase family. These compounds selectively inhibit EGF-R kinase activity at low nanomolar concentration and tyrosine autophosphorylation in cells expressing EGF-R or Her2 (p185(erbB)). Structure-activity relationships (SARs) for this class of compounds are presented.