945840-69-7

Basic information

• Product Name: 1H-PYRROLO[2,3-C]PYRIDINE, 7-BROMO-5-CHLORO-
• Synonyms: 1H-PYRROLO[2,3-C]PYRIDINE, 7-BROMO-5-CHLORO-;7-Bromo-5-chloro-1H-pyrrolo[2,3-c]pyridine
• CAS NO: 945840-69-7
• Molecular Formula: C7H4BrClN2
• Molecular Weight: 231.47706
• EINECS: -0
• Mol File: 945840-69-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1H-PYRROLO[2,3-C]PYRIDINE, 7-BROMO-5-CHLORO-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-PYRROLO[2,3-C]PYRIDINE, 7-BROMO-5-CHLORO-(945840-69-7)
• EPA Substance Registry System: 1H-PYRROLO[2,3-C]PYRIDINE, 7-BROMO-5-CHLORO-(945840-69-7)

Safety Data

• Hazardous Substances Data: 945840-69-7(Hazardous Substances Data)

Usage

General Description

1H-Pyrrolo[2,3-c]pyridine, 7-bromo-5-chloro- is a chemical compound with a unique heterocyclic structure characterized by a pyrrolopyridine ring system. It is distinguished by the presence of a bromine atom at the 7th position and a chlorine atom at the 5th position on the aromatic ring. 1H-Pyrrolo[2,3-c]pyridine, 7-bromo-5-chloro- is of interest in the field of medicinal chemistry and drug discovery due to its potential pharmacological properties. It may have applications in the development of novel pharmaceutical agents for various therapeutic indications. Additionally, it could be utilized as a building block in organic synthesis for the creation of diverse molecular structures with potential biological activities. Further research and investigation into the properties and potential applications of 1H-Pyrrolo[2,3-c]pyridine, 7-bromo-5-chloro- are warranted to fully understand its scientific and commercial potential.

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Relevant articles and documents

A Unique Approach to Design Potent and Selective Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) Inhibitors

The epigenetic regulator CBP/P300 presents a novel therapeutic target for oncology. Previously, we disclosed the development of potent and selective CBP bromodomain inhibitors by first identifying pharmacophores that bind the KAc region and then building into the LPF shelf. Herein, we report the "hybridization" of a variety of KAc-binding fragments with a tetrahydroquinoline scaffold that makes optimal interactions with the LPF shelf, imparting enhanced potency and selectivity to the hybridized ligand. To demonstrate the utility of our hybridization approach, two analogues containing unique Asn binders and the optimized tetrahydroquinoline moiety were rapidly optimized to yield single-digit nanomolar inhibitors of CBP with exquisite selectivity over BRD4(1) and the broader bromodomain family.

ALKYNYL ALCOHOLS AND METHODS OF USE

The invention relates to compounds of Formula (0): wherein A1-A8, R4 and R5 each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.