945893-19-6

Basic information

• Product Name: tert-butyl-4-bromo-2-({4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinolin-2-yl)ethyl]phenyl}carbamoyl)phenylcarbamate
• Synonyms: tert-butyl-4-bromo-2-({4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinolin-2-yl)ethyl]phenyl}carbamoyl)phenylcarbamate
• CAS NO: 945893-19-6
• Molecular Weight: 610.548
• Mol File: 945893-19-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl-4-bromo-2-({4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinolin-2-yl)ethyl]phenyl}carbamoyl)phenylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl-4-bromo-2-({4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinolin-2-yl)ethyl]phenyl}carbamoyl)phenylcarbamate(945893-19-6)
• EPA Substance Registry System: tert-butyl-4-bromo-2-({4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinolin-2-yl)ethyl]phenyl}carbamoyl)phenylcarbamate(945893-19-6)

Safety Data

• Hazardous Substances Data: 945893-19-6(Hazardous Substances Data)

Upstream product

• 5794-88-7 5-Bromo-2-aminobenzoic acid 
• 118-92-3 anthranilic acid 
• 306937-20-2 5-bromo-2-((tert-butoxycarbonyl)amino)benzoic acid 
• 82925-02-8 4-<2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolyl)ethyl>benzenamine 

Downstream Products

• 945893-20-9 2-amino-5-bromo-N-(4-{2-[6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinolin-2-yl]ethyl}-phenyl)benzamide 

Relevant articles and documents

Tariquidar analogues: Synthesis by CuI-catalysed N/O-aryl coupling and inhibitory activity against the ABCB1 transporter

Less lipophilic and better water soluble tariquidar analogues were synthesised from one central anthranilic acid derived building block by Cu I-catalysed N/O-arylation reactions. The compounds were tested for their inhibitory activity against the ABCB1 transporter in a flow cytometric calcein-AM efflux assay. A correlation between their calculated log P values and their activities was observed, with the more lipophilic analogues being as potent as the reference substance tariquidar. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.