945917-72-6 Usage
Description
(S)-indolizidine-1,3-dione, also known as quinolizidine-1,3-dione, is a heterocyclic compound belonging to the quinolizidine family. It is characterized by its molecular formula C8H5NO2 and is a cyclic diimide derivative of indolizidine. (S)-indolizidine-1,3-dione has garnered attention for its potential pharmacological activities, such as antimitotic and antitumor properties, and has been utilized as a building block in the synthesis of various bioactive compounds and pharmaceuticals. Furthermore, (S)-indolizidine-1,3-dione has demonstrated promise in materials science, particularly in the development of organic semiconductors and conducting polymers.
Uses
Used in Pharmaceutical Industry:
(S)-indolizidine-1,3-dione is used as a key intermediate for the synthesis of bioactive compounds and pharmaceuticals due to its potential pharmacological activities. Its antimitotic and antitumor properties make it a valuable component in the development of novel therapeutic agents.
Used in Materials Science:
(S)-indolizidine-1,3-dione is used as a building block in the development of organic semiconductors and conducting polymers. Its unique chemical structure and properties contribute to the advancement of these materials, which have applications in various electronic and optoelectronic devices.
Check Digit Verification of cas no
The CAS Registry Mumber 945917-72-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,5,9,1 and 7 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 945917-72:
(8*9)+(7*4)+(6*5)+(5*9)+(4*1)+(3*7)+(2*7)+(1*2)=216
216 % 10 = 6
So 945917-72-6 is a valid CAS Registry Number.
945917-72-6Relevant articles and documents
Bacterial Alkaloid Biosynthesis: Structural Diversity via a Minimalistic Nonribosomal Peptide Synthetase
Klapper, Martin,Braga, Daniel,Lackner, Gerald,Herbst, Rosa,Stallforth, Pierre
, p. 659 - 9,665 (2018/06/21)
Chemical and biochemical analyses of one of the most basic nonribosomal peptide synthetases (NRPS) from a Pseudomonas fluorescens strain revealed its striking plasticity. Determination of the potential substrate scope enabled us to anticipate novel secondary metabolites that could subsequently be isolated and tested for their bioactivities. Detailed analyses of the monomodular pyreudione synthetase showed that the biosynthesis of the bacterial pyreudione alkaloids does not require additional biosynthetic enzymes. Heterologous expression of a similar and functional, yet cryptic, NRPS of Pseudomonas entomophila was successful and allowed us to perform a phylogenetic analysis of their thioesterase domains. Nonribosomal peptides are a diverse class of ecologically and clinically relevant natural products. Here, Klapper et al. study one of the simplest bacterial nonribosomal peptide synthetases of different Pseudomonas strains. A single gene, encoding the monomodular pyreudione synthetase, leads to the production of a variety of bioactive alkaloids.
