94594-81-7 Usage
Description
(S)-(+)-(2-BUTENOYL)-2 10-CAMPHORSULTAM, also known as CAM-B, is a chiral building block derived from camphor and commonly used in organic synthesis. It features a unique conformation due to its rigid structure, making it a versatile compound for various transformations, including asymmetric catalysis and synthesis of chiral compounds. CAM-B plays a crucial role in influencing the stereochemistry of reactions and serves as an important intermediate for the production of pharmaceuticals, agrochemicals, and materials. Its ability to induce high enantioselectivity in reactions has garnered attention in the field of asymmetric synthesis, making it a valuable chemical for developing asymmetric synthesis strategies and producing chiral compounds with high optical purity.
Uses
Used in Pharmaceutical Industry:
(S)-(+)-(2-BUTENOYL)-2 10-CAMPHORSULTAM is used as a chiral building block for the synthesis of pharmaceuticals, contributing to the development of enantiomerically pure drugs with improved efficacy and reduced side effects.
Used in Agrochemical Industry:
(S)-(+)-(2-BUTENOYL)-2 10-CAMPHORSULTAM is used as a key intermediate in the production of agrochemicals, enabling the creation of enantiomerically pure pesticides and other agricultural compounds to enhance crop protection and yield.
Used in Materials Science:
(S)-(+)-(2-BUTENOYL)-2 10-CAMPHORSULTAM is used as a chiral component in the synthesis of advanced materials, such as chiral polymers and other materials with specific properties, for applications in various industries.
Used in Asymmetric Synthesis:
(S)-(+)-(2-BUTENOYL)-2 10-CAMPHORSULTAM is used as a catalyst or ligand in asymmetric synthesis, facilitating the production of chiral compounds with high enantioselectivity, which is crucial for the development of new pharmaceuticals, agrochemicals, and other specialty chemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 94594-81-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,4,5,9 and 4 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 94594-81:
(7*9)+(6*4)+(5*5)+(4*9)+(3*4)+(2*8)+(1*1)=177
177 % 10 = 7
So 94594-81-7 is a valid CAS Registry Number.
InChI:InChI=1/C14H21NO3S/c1-4-5-12(16)15-11-8-10-6-7-14(11,13(10,2)3)9-19(15,17)18/h4-5,10-11H,6-9H2,1-3H3/b5-4+/t10-,11-,14-/m0/s1
94594-81-7Relevant articles and documents
MACROCYCLIC SPIROETHERS AS MCL-1 INHIBITORS
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Paragraph 0535; 0536, (2020/07/31)
Provided are compounds represented by Formula (I-A) and the pharmaceutically acceptable salts and solvates thereof, wherein R8, R9a, R9b, R9c, R9d, X, Y, Z, Z1, W, and (aa) are as defined as set forth in the specification. Provided are also compounds of Formula (I-A) for use to treat a condition or disorder responsive to Mcl-1 inhibition such as cancer.
Progress toward the total synthesis of callipeltin A (I): Asymmetric synthesis of (3S,4R)-3,4-dimethylglutamine
Liang, Bo,Carroll, Patrick J.,Joullie, Madeleine M.
, p. 4157 - 4160 (2007/10/03)
(equation presented) During the total synthesis of the novel cyclic depsipeptide callipeltin A (1), the unit (3S,4R)-3,4-dimethylglutamine, was successfully synthesized by asymmetric Michael addition and subsequent electrophilic azidation. The key feature of this approach is the generation of three adjacent stereogenic centers using the same camphorsultam chiral auxiliary.
A practical method for N-acylation of bornane-2,10-sultam and 2-oxazolidinones
Thom,Kocienski
, p. 582 - 586 (2007/10/02)
The N-trimethylsilyl derivatives of (+)-bornane-2,10-sultam (10,10-dimethyl-5-thia-4-azatricyclo[5.2.1.03,7]decane 5,5-dioxide) and (R)-4-benzyl-2-oxazolidinone and 4-methyl-5-phenyl-2-oxazolidinone react with acid chlorides in refluxing benzen