94596-28-8

Basic information

• Product Name: Senkyunolide I
• Synonyms: (6α,7β)-3-[(Z)-Butylidene]-4,5,6,7-tetrahydro-6,7-dihydroxy-1(3H)-isobenzofuranone;Senkyunolide I;(3Z,6R,7R)-rel-3-Butylidene-4,5,6,7-tetrahydro-6,7-dihydroxy-1(3H)-isobenzofuranone
• CAS NO: 94596-28-8
• Molecular Formula: C₁₂H₁₆O₄
• Molecular Weight: 224.25300
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 94596-28-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.28
• CAS DataBase Reference: Senkyunolide I(CAS DataBase Reference)
• NIST Chemistry Reference: Senkyunolide I(94596-28-8)
• EPA Substance Registry System: Senkyunolide I(94596-28-8)

Safety Data

• Hazardous Substances Data: 94596-28-8(Hazardous Substances Data)

Usage

Description

Senkyunolide I is a bioactive phthalide derived from the root and stem exteriors of Angelica sinensis, a plant commonly known as Chinese angelica or Dong Quai. It is recognized for its potential therapeutic properties and has been the subject of scientific research.

Uses

Used in Pharmaceutical Industry:
Senkyunolide I is used as an anti-migraine compound for its potential to alleviate the symptoms of migraines. Its bioactive properties make it a promising candidate for the development of new treatments for migraine sufferers.
Used in Traditional Medicine:
Senkyunolide I is also utilized in traditional medicine, particularly in the context of Chinese medicine, where Angelica sinensis has been used for centuries for its various health benefits. Senkyunolide I contributes to the plant's overall therapeutic effects, which include but are not limited to the treatment of menstrual disorders, cardiovascular diseases, and as an anti-inflammatory agent.

Upstream product

• 81944-09-4 Z-ligustilide 
• 94530-85-5 senkyunolide-G 

Relevant articles and documents

Metabolism of Chuanxiong Rhizoma decoction: Identification of the metabolites in WZS-miniature pig urine

Abstract Chuanxiong Rhizoma (CR), a well-known traditional Chinese medicine originated from the rhizome of Ligusticum chuanxiong Hort., was effective for treating various vascular diseases. To identify the metabolites of CR in vivo, the drug-containing urine samples of WZS-miniature pigs after orally administrated CR decoction were collected, after sequential column chromatography 17 metabolites (M1-M17) were isolated from the methanol extract of the urine samples. Their structures, including nine phthalides (M1-M9) and eight phenolic acids (M10-M17), were identified by spectroscopic means. Among them, 8 were new ones (M1-M6, M11-M12). On the basis of the structures of identified metabolites, seven original constituents, including 2 phthalides (senkyunolideI/H) and 5 phenolic acids (ferulic acid, isoferulic acid, caffeic acid, 3-hydroxycinnamoyl acid and 4-hydroxybenzonic acid) were deduced to be the major absorbed original constituents of CR in vivo. This is the first study on the metabolites of CR decoction in non-rodent animal (WZS-miniature pig), the results will give an insight into the metabolism profiles of phthalides and phenolic acids in CR decoction in vivo.

Components of Cnidium officinale makino: Occurrence of pregnenolone, coniferyl ferulate, and hydroxyphthalides

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