946123-68-8

Basic information

• Product Name: 1,3-bis(4-formylphenyl)tetrahydropyrimidin-2(1H)-one
• Synonyms: 1,3-bis(4-formylphenyl)tetrahydropyrimidin-2(1H)-one
• CAS NO: 946123-68-8
• Molecular Weight: 308.337
• Mol File: 946123-68-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1,3-bis(4-formylphenyl)tetrahydropyrimidin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-bis(4-formylphenyl)tetrahydropyrimidin-2(1H)-one(946123-68-8)
• EPA Substance Registry System: 1,3-bis(4-formylphenyl)tetrahydropyrimidin-2(1H)-one(946123-68-8)

Safety Data

• Hazardous Substances Data: 946123-68-8(Hazardous Substances Data)

Upstream product

• 1852-17-1 3,4,5,6-tetrahydropyrimidin-2(1H)-one 
• 1122-91-4 4-bromo-benzaldehyde 

Downstream Products

• 946123-69-9 1,3-bis(4-hydroxyphenyl)tetrahydropyrimidinone 
• 1428236-85-4 C₂₂H₂₀N₂O₅ 
• 1428236-83-2 (E,E)-1,3-bis[4-(1-ethoxycarbonylethen-2-yl)phenyl]tetrahydropyrimidin-2(1H)-one 

Relevant articles and documents

Novel symmetrical ureas as modulators of protein arginine methyl transferases

Methylation of histone arginine residues is an epigenetic mark related to gene expression that is implicated in a variety of biological processes and can be reversed by small-molecule modulators of protein arginine methyltransferases (PRMTs). A series of symmetrical ureas, designed as analogues of the known PRMT1 inhibitor AMI-1 have been synthesized using Pd-catalyzed Ar-N amide bond formation processes or carbonylation reactions as key steps. Their inhibitory profile has been characterized. The enzymatic assays showed a weak effect on PRMT1 and PRMT5 activity for most of the compounds. The acyclic urea that exhibited the strongest effect on the inhibition of the PRMT1 activity also showed the greatest effect on the expression of some androgen receptor target genes (TMPRSS2 and FKBP5), which may be related with its enzymatic activity. Surprisingly, AMI-1 behaved as an activator of PRMT5 activity, a result not reported so far.