946130-11-6

Basic information

• Product Name: 2-(3-nitrophenylamino)-3-oxobutanoic acid ethyl ester
• Synonyms: 2-(3-nitrophenylamino)-3-oxobutanoic acid ethyl ester
• CAS NO: 946130-11-6
• Molecular Weight: 266.254
• Mol File: 946130-11-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(3-nitrophenylamino)-3-oxobutanoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-nitrophenylamino)-3-oxobutanoic acid ethyl ester(946130-11-6)
• EPA Substance Registry System: 2-(3-nitrophenylamino)-3-oxobutanoic acid ethyl ester(946130-11-6)

Safety Data

• Hazardous Substances Data: 946130-11-6(Hazardous Substances Data)

Upstream product

• 7705-07-9 titanium(III) chloride 
• 66552-44-1 methyl 2-(4-ethoxy-4-oxobut-2-en-2-yl)diazene-1-carboxylate 
• 99-09-2 3-nitro-aniline 
• 2009-97-4 ethyl 2-diazo-3-oxobutanoate 
• 946130-10-5 3-(methoxycarbonyl-hydrazono)-2-((3-nitrophenyl)amino)butyric acid ethyl ester 

Downstream Products

• 946127-04-4 3-(3-aminophenylamino)-7-hydroxy-4-methyl-2-oxo-2H-1-benzopyran 
• 946126-56-3 3-(3-aminophenylamino)-4-methyl-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran 
• 1104542-92-8 3-(3-(methylaminosulfonyl)aminophenylamino)-4-methyl-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran 
• 946125-87-7 7-hydroxy-4-methyl-3-(3-nitrophenylamino)-2-oxo-2H-1-benzopyran 

Relevant articles and documents

p27 PROTEIN INDUCER

The present invention provides a p27 protein inducing agent comprising a compound represented by general formula (11) below or pharmaceutically acceptable salt thereof as an active ingredient: wherein G 1 , G 2 , G 3 and G 8 are each independently selected from -N= etc., Ring G 6 is selected from divalent aryl etc., A is selected from amino etc., G 4 is selected from oxygen etc., G 5 is selected from oxygen etc., G 7 is selected from -CH 2 - etc., and R 2 is selected from C 1-6 alkyl etc.

A transformation of N-alkylated anilines to N-aryloxamates

Transformation of N-alkylated anilines to N-aryloxamates was studied using ethyl 2-diazoacetoacetate as an alkylating agent and dirhodium tetraacetate (Rh2(OAc)4) as the catalyst. The general applicability of the reaction as a synthetic method for N-aryloxamates was studied with a number of substituted N-alkylated anilines. The results revealed that the oxamate was formed by a radical reaction with molecular O2 and Rh 2(OAc)4 as initiator. Copyright

NOVEL COUMARIN DERIVATIVE HAVING ANTITUMOR ACTIVITY

The present invention provides a compound represented by general formula (1) below or a pharmaceutically acceptable salt thereof: wherein: X is selected from heteroaryl etc., Y1 and Y2 are selected from -N= etc., Y3 and Y4 are selected from -CH= etc., A is selected from sulfamide etc., R1 is selected from hydrogen etc., and R2 is selected from C1-6 alkyl etc. The compound or salt has sufficiently high antitumor activity, and is useful in the treatment of cell proliferative disorders, particularly cancers. The present invention also provides a pharmaceutical composition containing the compound or salt as an active ingredient.