946160-84-5

Basic information

• Product Name: C₂₂H₁₈BrClN₂O₄S
• CAS NO: 946160-84-5
• Molecular Weight: 521.819
• Mol File: 946160-84-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₁₈BrClN₂O₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₁₈BrClN₂O₄S(946160-84-5)
• EPA Substance Registry System: C₂₂H₁₈BrClN₂O₄S(946160-84-5)

Safety Data

• Hazardous Substances Data: 946160-84-5(Hazardous Substances Data)

Upstream product

• 551-93-9 2-aminoacetophenone 
• 932-96-7 N-methyl(p-chloroaniline) 
• 10130-89-9 p-carboxyphenylsulfonyl chloride 
• 668261-31-2 4-(N-(4-chlorophenyl)-N-methylsulfamoyl)benzoic acid 
• 666859-77-4 4-{ [ (4-CHLOROPHENYL) (methyl) amino] SULFONYL} benzoyl chloride 
• 29124-56-9 1-(2-amino-5-bromophenyl)ethanone 

Relevant articles and documents

Structure-activity relationships of bioisosteres of a carboxylic acid in a novel class of bacterial translation inhibitors

The discovery and initial optimization of a novel anthranilic acid derived class of antibacterial agents which suffered from extensive protein binding has been previously reported. The structure-activity relationships around the carboxylic acid substituent are described herein. This acid was replaced by several alternative functional groups in attempts to retain bioactivity while reducing protein binding. Only groups with an acidic proton retained activity, and analogs containing those groups maintained the protein binding inherent to this class of antibacterial agents.