946161-99-5

Basic information

• Product Name: 4-methyl-N-(4-methyl-2-phenylethynyl-phenyl)-benzenesulfonamide
• Synonyms: 4-methyl-N-(4-methyl-2-phenylethynyl-phenyl)-benzenesulfonamide
• CAS NO: 946161-99-5
• Molecular Weight: 361.464
• Mol File: 946161-99-5.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: 4-methyl-N-(4-methyl-2-phenylethynyl-phenyl)-benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-N-(4-methyl-2-phenylethynyl-phenyl)-benzenesulfonamide(946161-99-5)
• EPA Substance Registry System: 4-methyl-N-(4-methyl-2-phenylethynyl-phenyl)-benzenesulfonamide(946161-99-5)

Safety Data

• Hazardous Substances Data: 946161-99-5(Hazardous Substances Data)

Upstream product

• 536-74-3 phenylacetylene 
• 2903-37-9 N-(2-chloro-4-methylphenyl)-4-methylbenzenesulfonamide 
• 98-59-9 p-toluenesulfonyl chloride 
• 29289-13-2 2-iodo-4-methylaniline 
• 852292-23-0 N-(2-iodo-4-methylphenyl)-4-methylbenzenesulfonamide 
• 13141-44-1 4-methyl-2-(phenylethynyl)aniline 

Downstream Products

• 1616349-88-2 2-(5-methyl-2-phenyl-1-tosyl-1H-indol-4-yl)-1-(p-tolyl)ethanone 
• 1616350-44-7 2-(5-methyl-2-phenyl-1-tosyl-1H-indol-4-yl)cyclopentanone 
• 1616350-39-0 1-(4-methoxyphenyl)-2-(5-methyl-2-phenyl-1-tosyl-1H-indol-4-yl)propan-1-one 
• 1616350-38-9 1-(4-bromophenyl)-2-(5-methyl-2-phenyl-1-tosyl-1H-indol-4-yl)ethanone 
• 1616350-36-7 1-(4-methoxyphenyl)-2-(5-methyl-2-phenyl-1-tosyl-1H-indol-4-yl)ethanone 
• 1616350-34-5 2-(5-methyl-2-phenyl-1-tosyl-1H-indol-4-yl)-1-phenylethanone 
• 1388135-99-6 7-(4-methoxyphenyl)-5-methyl-1-phenyl-2-tosyl-6,7-dihydro-2H-cyclopenta[cd]indole 
• 1388136-42-2 5-methyl-4-methoxy-2-phenyl-1-tosyl-1H-indole 

Relevant articles and documents

Stereoselective synthesis of 2,3-disubstituted indoline, pyrrolidine and cyclic ether-fused 1,2-dihydroquinoline derivatives using alkyne iminium ion cyclization of vinylogous carbamates: Switch of regioselectivity using an internal hydroxy group as a nucleophile

An intramolecular, alkyne iminium ion cyclization of vinylogous carbamates derived from o-alkynyl anilines and N-protected homopropargyl amines is developed for the stereoselective construction of trans-2,3-disubstituted indolines and pyrrolidine derivatives, respectively. The regioselectivity of the alkyne iminium ion cyclization could be switched using a hydroxy group as an internal nucleophile resulting in cyclic ether-fused 1,2-dihydroquinolines. The entire process of nitrogen heterocycle formation can also be carried out in a 'one-pot' manner starting from o-iodo aniline derivatives.

Synthesis of 3-Methylthioindoles via Intramolecular Cyclization of 2-Alkynylanilines Mediated by DMSO/DMSO-d6 and SOCl2

The intramolecular cyclization of 2-alkynylanilines mediated by DMSO/SOCl2 was found to afford biologically interesting 3-methylthioindoles, which are rarely obtained by the exiting methods. DMSO could also be replaced with its deuterated count

Nickel-Catalyzed Arylative Additions on 2-Alkynyl-N-Arylsulfonylanilides to Construct Functionalized Indoles

The addition of aryl iodides to 2-alkynyl-N-sulfonylanilides to form 2,3-difunctionalized N-arylsulfonylindoles can be catalyzed using a nickel catalyst ligated to a bis(cyclohexanyl)phosphinoferrocene. A variety of nickel complexes can be used as precata