94617-77-3Relevant articles and documents
Tungstate-Catalyzed Oxidation of Secondary Amines to Nitrones. α-Substitution of Secondary Amines via Nitrones
Murahashi, Shun-Ichi,Mitsui, Hitoshi,Shiota, Tatsuki,Tsuda, Tomoyasu,Watanabe, Shoji
, p. 1736 - 1744 (1990)
The sodium tungstate catalyzed oxidation of secondary amines with hydrogen peroxide gives the corresponding nitrones.Acyclic and cyclic nitrones can be obtained from secondary amines in a single step in good to escellent yields.The oxidation of secondary amines in the presence of alkenes gives isoxazolidines by 1,3-dipolar cycloaddition of nitrones.Introduction of a substituent at the α-position of secondary amines can be performed upon oxidation of secondary amines and subsequent treatment with various nucleophiles.