946517-36-8 Usage
Description
(S)-Naproxen Acyl-β-D-glucuronide Benzyl Ester, with the chemical abstracts service number 946517-36-8, is a specialized compound that plays a significant role in the field of organic synthesis. This molecule is characterized by its unique structure, which includes a naproxen moiety acylated to a β-D-glucuronide group, with a benzyl ester functional group attached. The synthesis of such compounds is crucial for the development of new pharmaceutical agents and the exploration of novel chemical reactions.
Uses
Used in Organic Synthesis:
(S)-Naproxen Acyl-β-D-glucuronide Benzyl Ester is used as a key intermediate in organic synthesis for the development of new chemical entities. Its unique structure allows for further functionalization and modification, making it a valuable building block for creating complex organic molecules with potential applications in various fields.
Used in Pharmaceutical Development:
In the pharmaceutical industry, (S)-Naproxen Acyl-β-D-glucuronide Benzyl Ester is utilized as a precursor in the synthesis of drug candidates. Its ability to be modified and functionalized makes it an attractive starting point for the design of new medications, particularly those targeting specific biological pathways or receptors.
Used in Research and Development:
(S)-Naproxen Acyl-β-D-glucuronide Benzyl Ester is also employed in academic and industrial research settings. Scientists use this compound to study various aspects of organic chemistry, such as reaction mechanisms, stereochemistry, and the development of new synthetic methods. Additionally, it can be used to investigate the properties of β-D-glucuronide and benzyl ester functional groups in different chemical contexts.
Check Digit Verification of cas no
The CAS Registry Mumber 946517-36-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,6,5,1 and 7 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 946517-36:
(8*9)+(7*4)+(6*6)+(5*5)+(4*1)+(3*7)+(2*3)+(1*6)=198
198 % 10 = 8
So 946517-36-8 is a valid CAS Registry Number.
946517-36-8Relevant articles and documents
Efficient synthesis of 1β-O-acyl glucuronides via selective acylation of allyl or benzyl d-glucuronate
Bowkett, Elizabeth R.,Harding, John R.,Maggs, James L.,Park, B. Kevin,Perrie, Jennifer A.,Stachulski, Andrew V.
, p. 7596 - 7605 (2007)
Acyl glucuronides are key metabolites for many carboxylic acid-containing drugs, notably those of the non-steroidal anti-inflammatory class. In the processes of drug safety assessment and new drug development, it is essential that acyl glucuronides, if formed in vivo, should be made conveniently available for bioevaluation. We recently showed that selective acylation of allyl glucuronate is a promising method for the synthesis of these metabolites in good yield and with excellent β-anomeric selectivity. We now give fuller details of the allyl ester method and further report that benzyl glucuronate performs at least equally well in the acylation step, offering the advantage of very mild deprotection by catalytic transfer (or conventional) hydrogenation. Depending on the compatibility of other functional groups, as discussed below, this will be the method of choice for many acyl glucuronide syntheses. The value of the method is demonstrated in particular by the synthesis of several acyl glucuronides that are known metabolites of important drugs.