94662-50-7Relevant articles and documents
A potent gastric acid anti-secretory histamine H2 receptor antagonist, N--2-furanyl>methyl>thio>ethyl>thienoisothiazol-3-amine 1,1-dioxide, hydrochloride (Wy-45,727)
Santilli, Arthur A.,Scotese, Anthony C.,Morris, Robert L.,Nielsen, Susan T.,Strike, Donald P.
, p. 87 - 90 (1989)
The synthesis of the title compound, a new histamine H2-receptor antagonist (pA2=8.2), (Wy-45,727;7) is described.Its gastric acid anti-secretory potencies in the rat and dog were found to be significantly greater than those of cimetidine or ranitidine. anti-secretory / H2-receptor antagonist / N--2-furanyl>methyl>thio>ethyl>thieno-isothiazol-3-amine 1,1-dioxide hydrochloride / Wy-45,727
Process for preparing thieno-fused heterocyclic anti-ulcer agents
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, (2008/06/13)
A process for preparing certain thieno-fused heterocyclic compounds having H2 -receptor antagonist and antisecretory activity, which comprises reacting a suitable thienoisothiazole derivative with an appropriate (furanylmethylthio)ethanamine derivative to yield an intermediate, which is subjected to cyclization to yield the desired final product.