94664-82-1

Basic information

• Product Name: Butanoic acid, 4-hydroxy-3-[[(phenylmethoxy)carbonyl]amino]-, (S)-
• Synonyms: (3S)-4-hydroxy-3-({[(phenylmethyl)oxy]carbonyl}amino)butanoic acid;3(S)-(benzyloxycarbonylamino)-4-hydroxybutanoic acid
• CAS NO: 94664-82-1
• Molecular Formula: C12H15NO5
• Molecular Weight: 253.255
• Mol File: 94664-82-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 4-hydroxy-3-[[(phenylmethoxy)carbonyl]amino]-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 4-hydroxy-3-[[(phenylmethoxy)carbonyl]amino]-, (S)-(94664-82-1)
• EPA Substance Registry System: Butanoic acid, 4-hydroxy-3-[[(phenylmethoxy)carbonyl]amino]-, (S)-(94664-82-1)

Safety Data

• Hazardous Substances Data: 94664-82-1(Hazardous Substances Data)

Upstream product

• 87219-29-2 benzyl (3S)-5-oxotetrahydro-3-furanylcarbamate 
• 1152-61-0 N-Cbz-L-Asp 
• 4515-23-5 N-benzyloxycarbonyl-L-aspartic acid anhydride 
• 4515-22-4 Z-D-Asp-anhydride 
• 146398-02-9 tert-butyl (S)-3-benzyloxycarbonylamino-4-hydroxybutyrate 

Downstream Products

• 1228188-06-4 phenylmethyl ((1S)-2-{[(1,1-dimethylethyl)(diphenyl)silyl]oxy}-1-{[2-(hydroxymethyl)cyclopropyl]methyl}ethyl)carbamate 
• 1228188-05-3 C₃₁H₃₉NO₄Si 
• 1228188-03-1 methyl (2Z,5S)-6-{[(1,1-dimethylethyl)(diphenyl)silyl]oxy}-5-({[(phenylmethyl)oxy]carbonyl}amino)-2-hexenoate 
• 1228188-04-2 phenylmethyl [(1S,3Z)-1-({[(1,1-dimethylethyl)(diphenyl)silyl]oxy}methyl)-5-hydroxy-3-penten-1-yl]carbamate 
• 1228188-07-5 phenylmethyl (1S,4S,6S)-4-({[(1,1-dimethylethyl)(diphenyl)silyl]oxy}methyl)-3-azabicyclo[4,1,0]heptane-3-carboxylate 
• 1228188-00-8 methyl (3S)-4-{[(1,1-dimethylethyl)(diphenyl)silyl]oxy}-3-({[(phenylmethyl)oxy]carbonyl}amino)butanoate 
• 1228188-02-0 phenylmethyl [(1S)-1-({[(1,1-dimethylethyl)(diphenyl)silyl]oxy}methyl)-3-hydroxypropyl]carbamate 
• 1228188-10-0 phenylmethyl (1S,4S,6S)-4-({[5-(trifluoromethyl)-2-pyridinyl]amino}methyl)-3-azabicyclo[4,1,0]heptane-3-carboxylate 
• 1228188-01-9 phenylmethyl [(1S)-1-({[(1,1-dimethylethyl)(diphenyl)silyl]oxy}methyl)-3-oxopropyl]carbamate 
• 1228188-08-6 phenylmethyl (1S,4S,6S)-4-(hydroxymethyl)-3-azabicyclo[4,1,0]heptane-3-carboxylate 
• 1228188-09-7 phenylmethyl (1S,4S,6S)-4-formyl-3-azabicyclo[4,1,0]heptane-3-carboxylate 
• 192517-47-8 methyl (3S)-3-[[(benzyloxy)carbonyl]amino]-4-hydroxybutanoate 
• 461009-54-1 (S)-3-(((benzyloxy)carbonyl)amino)-4-((tert-butyldiphenylsilyl)oxy)butanoic acid 
• 574005-84-8 (2R,3R)-3-Benzyloxycarbonylamino-4-(tert-butyl-dimethyl-silanyloxy)-2-iodo-butyric acid benzyl ester 

Relevant articles and documents

N-{[(IR,4S,6R-3-(2-PYRIDINYLCARBONYL)-3-AZABICYCLO [4.1.0] HEPT-4-YL] METHYL}-2-HETEROARYLAMINE DERIVATIVES AND USES THEREOF

This invention relates to N-{[(1S,4S,6S)-3-(2-pyridinylcarbonyl)-3-azabicyclo[4.1.0]hept-4-yl]methyl}-2-heteroarylamine derivatives and their use as pharmaceuticals.

A new entry to polyfunctionalized 4,5-trans disubstituted oxazolidin-2-ones from L-aspartic acid

A straightforward synthesis of enantiomerically pure (4R,5S)-5-oxazolidinecarboxylic acid, 2-oxo-4-[(t-butyldimethyl-silyloxy)methyl]-, benzyl ester and of (4S,5S)-4-oxazolidinecarboxylic acid, 2-oxo-5-[(t-butyldimethylsilyloxy)methyl]-, benzyl ester was envisaged starting from readily available L-aspartic acid. The key step is the diastereoselective addition of iodine with the introduction of a new stereogenic centre.

Cleavage of MEM ethers by tetrahalozincate reagents

A modification of the zinc halide-mediated removal of the MEM group is described. By the expedient of adding two molar equivalents of ethereal hydrogen chloride or of lithium halide, the method is extended to substrates which otherwise chelate the zinc reagent without undergoing deprotection. The compatibility of the resulting reagent Systems with other functional groups is demonstrated, and examples are presented where deprotection of mono-MEM-protected 1,2- and 1,3-diols can be carried out, avoiding the cyclisation which occurs normally.