94665-48-2 Usage
Description
(4R,5R)-4,5-Bis-(diphenyl-phosphinoylmethyl)-2,2-dimethyl-[1,3]dioxolane is a complex organic compound characterized by its unique structure and functional groups. It features a dioxolane ring with two methyl groups at the 2nd and 2nd carbon atoms, and two diphenyl-phosphinoylmethyl groups attached to the 4th and 5th carbon atoms. (4R,5R)-4,5-Bis-(diphenyl-phosphinoylmethyl)-2,2-dimethyl-[1,3]dioxolane is known for its chiral properties, which play a crucial role in its applications.
Uses
Used in Asymmetric Catalysis:
(4R,5R)-4,5-Bis-(diphenyl-phosphinoylmethyl)-2,2-dimethyl-[1,3]dioxolane is used as a chiral ligand in the field of asymmetric catalysis. Its application is particularly relevant in metal-catalyzed asymmetric hydrogenation reactions. The chiral nature of the compound allows it to selectively bind to certain metal catalysts, thereby influencing the stereochemistry of the reaction. This selective binding is essential for the synthesis of chiral compounds, which are vital in various industries, including pharmaceuticals and agrochemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (4R,5R)-4,5-Bis-(diphenyl-phosphinoylmethyl)-2,2-dimethyl-[1,3]dioxolane is used as a key intermediate in the synthesis of chiral drugs. The ability of this compound to selectively bind to metal catalysts and influence the stereochemistry of reactions is crucial for producing the desired enantiomers of chiral drugs. These enantiomers often exhibit different biological activities, and the compound's role in controlling this aspect is invaluable in drug development.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, (4R,5R)-4,5-Bis-(diphenyl-phosphinoylmethyl)-2,2-dimethyl-[1,3]dioxolane is utilized in the synthesis of chiral pesticides and other agrochemicals. (4R,5R)-4,5-Bis-(diphenyl-phosphinoylmethyl)-2,2-dimethyl-[1,3]dioxolane's chiral properties enable the production of specific enantiomers with desired biological activities, ensuring the effectiveness and selectivity of these products in controlling pests and diseases while minimizing their impact on non-target organisms and the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 94665-48-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,4,6,6 and 5 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 94665-48:
(7*9)+(6*4)+(5*6)+(4*6)+(3*5)+(2*4)+(1*8)=172
172 % 10 = 2
So 94665-48-2 is a valid CAS Registry Number.
94665-48-2Relevant articles and documents
Enantioselective chlorinative aldol reaction of α-substituted acroleins catalyzed by chiral phosphine oxides
Kotani, Shunsuke,Hanamure, Takuya,Nozaki, Hirono,Sugiura, Masaharu,Nakajima, Makoto
supporting information, p. 282 - 287 (2017/02/18)
The enantioselective chlorinative aldol reaction of α-substituted acroleins with aldehydes catalyzed by chiral phosphine oxides is described. A hypervalent silicon complex-derived chloride adds to the α-substituted acroleins to form the corresponding sily
Diastereo- and enantioselective reductive aldol reaction with trichlorosilane using Chiral Lewis bases as organocatalysts
Sugiura, Masaharu,Sato, Norimasa,Sonoda, Yuko,Kotani, Shunsuke,Nakajima, Makoto
supporting information; experimental part, p. 478 - 481 (2010/09/04)
Chiral Lewis base organocatalysts activate trichlorosilane to promote the tandem conjugate reduction/aldol reaction of α, β-unsaturated ketones with aldehydes to give optically active β-hydroxy ketones with good to high syn diastereo- and enantioselectivi
The solution structures of chiral Ti(4+) alkoxides. II. The roles of diolate basicity and side-chain binding group polarity
Bianchet, Stephen,Potvin, Pierre G.
, p. 2256 - 2265 (2007/10/02)
With a view to reproduce the structures in solution of the Katsuki-Sharpless catalyst (the dimeric complex formed by homochiral diisopropyl tartrate with Ti(OiPr)4), five C2-symmetric chiral 2,3-butanediols, related to L-threitol but
