946846-46-4Relevant articles and documents
Synthesis and biological evaluation of l-cysteine derivatives as mitotic kinesin Eg5 inhibitors
Ogo, Naohisa,Oishi, Shinya,Matsuno, Kenji,Sawada, Jun-ichi,Fujii, Nobutaka,Asai, Akira
, p. 3921 - 3924 (2007)
Inhibition of Eg5 represents a novel approach for the treatment of cancer. Here, we report the synthesis and structure-activity relationship of S-trityl-l-cysteine (STLC) derivatives as Eg5 inhibitors. Some of these derivatives such as 4f demonstrated enh