94686-44-9

Basic information

• Product Name: diphenyl-propoxy-acetic acid propyl ester
• Synonyms: diphenyl-propoxy-acetic acid propyl ester
• CAS NO: 94686-44-9
• Molecular Weight: 312.409
• Mol File: 94686-44-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: diphenyl-propoxy-acetic acid propyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: diphenyl-propoxy-acetic acid propyl ester(94686-44-9)
• EPA Substance Registry System: diphenyl-propoxy-acetic acid propyl ester(94686-44-9)

Safety Data

• Hazardous Substances Data: 94686-44-9(Hazardous Substances Data)

Upstream product

• 71-23-8 propan-1-ol 
• 56290-12-1 chloro-diphenyl-acetic acid propyl ester 
• 76-93-7 Benzilic acid 

Downstream Products

• 54556-98-8 propiverine hydrochloride 
• 47030-01-3 2,2-diphenyl-2-propoxyethanoic acid 

Relevant articles and documents

SYNTHESIS OF PROPIVERINE HYDROCHLORIDE

The present invention provides a two step esterification process for the synthesis of Propiverine hydrochloride. In the synthetic scheme disclosed herein benzillic acid 1 is directly converted to di-propyl ester ether 7 from the known standard method. The intermediate thus obtained is reacted with N-Methyl 4-hydroxy piperidine in the presence of sodium t-butoxide at room temperature to get Propiverine base 5. This is then finally converted to Propiverine hydrochloride. The process of synthesis provides Propiverine hydrochloride in a very pure form (>99%) with a very good yield. The compound is very useful in treating urinary incontinence.