947233-24-1

Basic information

• Product Name: 5-(benzyloxymethyl)-3-phenyloxazolidin-2-one
• Synonyms: 5-(benzyloxymethyl)-3-phenyloxazolidin-2-one
• CAS NO: 947233-24-1
• Molecular Weight: 283.327
• Mol File: 947233-24-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 5-(benzyloxymethyl)-3-phenyloxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(benzyloxymethyl)-3-phenyloxazolidin-2-one(947233-24-1)
• EPA Substance Registry System: 5-(benzyloxymethyl)-3-phenyloxazolidin-2-one(947233-24-1)

Safety Data

• Hazardous Substances Data: 947233-24-1(Hazardous Substances Data)

Upstream product

• 2930-05-4 Benzyloxymethyl-oxiran 
• 62-53-3 aniline 
• 616-38-6 carbonic acid dimethyl ester 
• 103-71-9 phenyl isocyanate 
• 3422-01-3 tert-butyl phenylcarbamate 

Downstream Products

• 29218-21-1 5-(hydroxymethyl)-3-phenyl-2-oxooxazolidine 

Relevant articles and documents

Microwave-Assisted Electrostatically Enhanced Phenol-Catalyzed Synthesis of Oxazolidinones

An electrostatically enhanced phenol is utilized as a straightforward, sustainable, and potent one-component organocatalyst for the atom-economic transformation of epoxides to oxazolidinones under microwave irradiation. Integrating a positively charged center into phenols over a modular one-step preparation gives rise to a bifunctional system with improved acidity and activity, competent in rapid assembly of epoxides and isocyanates under microwave irradiation in a short reaction time (20-60 min). A careful assessment of the efficacy of various positively charged phenols and anilines and the impact of several factors, such as catalyst loading, temperature, and the kind of nucleophile, on catalytic reactivity were examined. Under neat conditions, this one-component catalytic platform was exploited to prepare more than 40 examples of oxazolidinones from a variety of aryl- and alkyl-substituted epoxides and isocyanates within minutes, where up to 96% yield and high degree of selectivity were attained. DFT calculations to achieve reaction barriers for different catalytic routes were conducted to provide mechanistic understanding and corroborated the experimental findings in which concurrent epoxide ring-opening and isocyanate incorporation were proposed.

Triethylamine Hydroiodide as a Bifunctional Catalyst for the Solvent-Free Synthesis of 2-Oxazolidinones

Among the wide variety of heterocycles, 2-oxazolidinones are recognized as some of the most important heterocyclic compounds in medicinal chemistry. Therefore, the development of a practical method for their synthesis would be an important development. He

Tetraarylphosphonium Salt-Catalyzed Synthesis of Oxazolidinones from Isocyanates and Epoxides

Preparation of a range of oxazolidinones, including enantioenriched N-aryl-substituted oxazolidinones, in which tetraarylphosphonium salts (TAPS) catalyze the [3 + 2] coupling reaction of isocyanates and epoxides effectively, is described. The key finding is a Br?nsted acid/halide ion bifunctional catalyst that can accelerate epoxide ring opening with high regioselectivity. Mechanistic studies disclosed that the ylide generated from TAPS, along with the formation of halohydrins, plays a crucial role in the reaction with isocyanates.