947371-20-2

Basic information

• Product Name: N-[(1S,2S)-2-(3-cyano-5-fluorophenyl)-3-(4-hydroxyphenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide
• Synonyms: N-[(1S,2S)-2-(3-cyano-5-fluorophenyl)-3-(4-hydroxyphenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide
• CAS NO: 947371-20-2
• Molecular Weight: 515.507
• Mol File: 947371-20-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[(1S,2S)-2-(3-cyano-5-fluorophenyl)-3-(4-hydroxyphenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(1S,2S)-2-(3-cyano-5-fluorophenyl)-3-(4-hydroxyphenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide(947371-20-2)
• EPA Substance Registry System: N-[(1S,2S)-2-(3-cyano-5-fluorophenyl)-3-(4-hydroxyphenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide(947371-20-2)

Safety Data

• Hazardous Substances Data: 947371-20-2(Hazardous Substances Data)

Upstream product

• 179898-34-1 3-bromo-5-fluorobenzonitrile 
• 947371-19-9 C₂₇H₂₄ClF₄N₃O₂ 

Relevant articles and documents

Discovery of N-{(1S,2S)-2-(3-cyanophenyl)-3-[4-(2-[18F] fluoroethoxy)phenyl]-1-methylpropyl}-2-methyl-2-[(5-methylpyridin-2-yl)oxy] propanamide, a cannabinoid-1 receptor positron emission tomography tracer suitable for clinical use

The discovery of a structurally distinct cannabinoid-1 receptor (CB1R) positron emission tomography tracer is described. Starting from an acyclic amide CB1R inverse agonist (1) as the lead compound, an efficient route to introduce 18F to the mo