947403-51-2

Basic information

• Product Name: C₂₁H₁₈ClN₅O₂S
• Synonyms: C₂₁H₁₈ClN₅O₂S
• CAS NO: 947403-51-2
• Molecular Weight: 439.925
• Mol File: 947403-51-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₁₈ClN₅O₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₁₈ClN₅O₂S(947403-51-2)
• EPA Substance Registry System: C₂₁H₁₈ClN₅O₂S(947403-51-2)

Safety Data

• Hazardous Substances Data: 947403-51-2(Hazardous Substances Data)

Upstream product

• 5407-51-2 benzothiazole-2,6-diamine 
• 214470-68-5 7-(3-chloro-propoxy)-4-chloro-6-methoxy-quinoline-3-carbonitrile 

Relevant articles and documents

The design, synthesis and biological evaluation of 7-alkoxy-4-heteroarylamino-3-cyanoquinolines as dual inhibitors of c-Src and iNOS

Because both c-Src and iNOS are key regulatory enzymes in tumorigenesis, a new series of 4-heterocycle amine-3-quinolinecarbonitriles as potent dual inhibitors of both enzymes were designed, synthesized and evaluated as multiple targets agents in cancer therapy. All compounds were evaluated by two related enzyme inhibition assays and an anti-proliferation assay in vitro. The results showed that most compounds inhibited c-Src and iNOS well. The best compound 8 inhibited both enzymes with the IC50 values of 34.8 nM and 26.7 μM. Several compounds also showed moderate anti-proliferation at 10 μM against colon and liver cancer cell lines.