947601-81-2

Basic information

• Product Name: DIEXO-3-AMINO-BICYCLO[2.2.1]HEPT-5-ENE-2-CARBOXYLIC ACID HYDROCHLORIDE
• Synonyms: DIEXO-3-AMINO-BICYCLO[2.2.1]HEPT-5-ENE-2-CARBOXYLIC ACID HYDROCHLORIDE
• CAS NO: 947601-81-2
• Molecular Formula: C8H12ClNO2
• Molecular Weight: 189.64
• Product Categories: Alicyclic Amino AcidsCarbonyl Compounds;C8;Carboxylic Acids;Peptide Synthesis;Unnatural Amino Acid Derivatives
• Mol File: 947601-81-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: DIEXO-3-AMINO-BICYCLO[2.2.1]HEPT-5-ENE-2-CARBOXYLIC ACID HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: DIEXO-3-AMINO-BICYCLO[2.2.1]HEPT-5-ENE-2-CARBOXYLIC ACID HYDROCHLORIDE(947601-81-2)
• EPA Substance Registry System: DIEXO-3-AMINO-BICYCLO[2.2.1]HEPT-5-ENE-2-CARBOXYLIC ACID HYDROCHLORIDE(947601-81-2)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 947601-81-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H11NO2.ClH/c9-7-5-2-1-4(3-5)6(7)8(10)11;/h1-2,4-7H,3,9H2,(H,10,11);1H/t4-,5+,6+,7-;/m0./s1

Upstream product

• 14735-70-7 diexo-3-Aza-4-oxotricyclo<4.2.1.0^2,5>non-7-ene 
• 924272-78-6 (1R,2R,5S,6S)-3-azatricyclo[4.2.1.0^2,5]non-7-en-4-one 

Relevant articles and documents

Synthesis of enantiopure 1,4-ethyl- and 1,4-ethylene-bridged cispentacin by lipase-catalyzed enantioselective ring opening of β-lactams

1,4-Ethyl- and 1,4-ethylene-bridged cispentacin enantiomers 1a, 1c and 2a, 2c were prepared through the lipase-catalyzed enantioselective ring opening of racemic exo-3-azatricyclo[4.2.1.02.5]nonan-4-one, (±)-1, and exo-3-azatricyclo[4.2.1.02.5]non-7-en-4-one, (±)-2. High enantioselectivity (E >200) was observed when the Lipolase-catalyzed reactions were performed with 1equiv of H2O in diisopropyl ether at 70°C. The resolved β-amino acids 1a and 2a (yield 46%) and β-lactams 1b and 2b (yield≥40%) could be easily separated. The ring opening of lactam enantiomers with 18% HCl afforded the corresponding β-amino acid hydrochloride enantiomers (ee ≥98%).