947740-21-8

Basic information

• Product Name: {7-[2-bromo-6-(4-trifluoromethyl-phenylethynyl)-pyridin-4-ylsulfanyl]-indan-4-yloxy}-acetic acid methyl ester
• Synonyms: {7-[2-bromo-6-(4-trifluoromethyl-phenylethynyl)-pyridin-4-ylsulfanyl]-indan-4-yloxy}-acetic acid methyl ester
• CAS NO: 947740-21-8
• Molecular Weight: 562.407
• Mol File: 947740-21-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {7-[2-bromo-6-(4-trifluoromethyl-phenylethynyl)-pyridin-4-ylsulfanyl]-indan-4-yloxy}-acetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {7-[2-bromo-6-(4-trifluoromethyl-phenylethynyl)-pyridin-4-ylsulfanyl]-indan-4-yloxy}-acetic acid methyl ester(947740-21-8)
• EPA Substance Registry System: {7-[2-bromo-6-(4-trifluoromethyl-phenylethynyl)-pyridin-4-ylsulfanyl]-indan-4-yloxy}-acetic acid methyl ester(947740-21-8)

Safety Data

• Hazardous Substances Data: 947740-21-8(Hazardous Substances Data)

Upstream product

• 1641-41-4 4-indanol 
• 40731-98-4 4-hydroxy-2,3-dihydroindan-1-one 
• 600176-68-9 (7-Mercapto-indan-4-yloxy)-acetic acid methyl ester 
• 779197-61-4 (7-thiocyanato-indan-4-yloxy)-acetic acid methyl ester 
• 600176-67-8 7-Thiocyanato-indan-4-ol 
• 868835-01-2 [7-(2,6-dibromo-pyridin-4-ylsulfanyl)-indan-4-yloxy]-acetic acid methyl ester 
• 705-31-7 4-trifluoromethylphenylacetylene 

Downstream Products

• 947740-22-9 {7-[2-(3-morpholin-4-yl-prop-1-ynyl)-6-(4-trifluoromethylphenylethynyl)-pyridin-4-ylsulfanyl]-indan-4-yloxy}-acetic acid methyl ester 

Relevant articles and documents

Design of a partial PPARδ agonist

Structure based ligand design was used in order to design a partial agonist for the PPARδ receptor. The maximum activation in the transactivation assay was reduced from 87% to 39%. The crystal structure of the ligand binding domain of the PPARδ receptor in complex with compound 2 was determined in order to understand the structural changes which gave rise to the decrease in maximum activation.