947763-54-4

Basic information

• Product Name: 4-Chloro-7-ethoxy-6-Methoxyquinoline
• Synonyms: 4-Chloro-7-ethoxy-6-Methoxyquinoline
• CAS NO: 947763-54-4
• Molecular Formula: C12H12ClNO2
• Molecular Weight: 237.68218
• Mol File: 947763-54-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Chloro-7-ethoxy-6-Methoxyquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-7-ethoxy-6-Methoxyquinoline(947763-54-4)
• EPA Substance Registry System: 4-Chloro-7-ethoxy-6-Methoxyquinoline(947763-54-4)

Safety Data

• Hazardous Substances Data: 947763-54-4(Hazardous Substances Data)

Upstream product

• 205448-31-3 4-chloro-6-methoxy-7-hydroxyquinoline 
• 64-17-5 ethanol 
• 75-03-6 ethyl iodide 

Relevant articles and documents

Discovery of small molecule FLT3 inhibitors that are able to overcome drug-resistant mutations

Herein we report the discovery of 1-(5-(tert-butyl)isoxazol-3-yl)-3- (3-fluorophenyl)urea derivatives as new FLT3 inhibitors that are able to overcome the drug resistance mutations: the secondary D835Y and F691L mutations on the basis of the internal tandem duplications (ITD) mutation of FLT3 (FLT3-ITD/D835Y and FLT3-ITD/F691L, respectively). The most potent compound corresponds to 1-(5-(tert-butyl)isoxazol-3-yl)-3-(4-((6,7-dimethoxyquinolin-4-yl)oxy)-3- fluorophenyl)urea (4d), which showed IC50s (half maximal inhibitory concentrations) of 0.072 nM, 5.86 nM and 3.48 nM against FLT3-ITD, FLT3-ITD/F691L and FLT3-ITD/D835Y, respectively. Compound 4d also showed good selectivity for FLT3 in a kinase profiling assay. Collectively, 4d could be a good lead compound and deserves further in-depth studies.