94805-83-1

Basic information

• Product Name: Isolicoflavonol
• Synonyms: Isolicoflavonol
• CAS NO: 94805-83-1
• Molecular Formula: C₂₀H₁₈O₆
• Molecular Weight: 354.35332
• Mol File: 94805-83-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 601.2±55.0 °C(Predicted)
• Appearance: /
• Density: 1.444±0.06 g/cm3(Predicted)
• PKA: 6.32±0.40(Predicted)
• CAS DataBase Reference: Isolicoflavonol(CAS DataBase Reference)
• NIST Chemistry Reference: Isolicoflavonol(94805-83-1)
• EPA Substance Registry System: Isolicoflavonol(94805-83-1)

Safety Data

• Hazardous Substances Data: 94805-83-1(Hazardous Substances Data)

Usage

General Description

Isolicoflavonol is a type of flavonoid, a class of natural compounds found in various plants. It is a yellow crystalline substance that is soluble in polar solvents such as ethanol and methanol. Isolicoflavonol has been identified in several plants, including Psoralea corylifolia, Sophora japonica, and Pueraria lobata. It has been studied for its potential biological activities, including antioxidant, anti-inflammatory, and anti-cancer properties. Isolicoflavonol has also been researched for its potential role in improving cardiovascular health and reducing the risk of chronic diseases. Overall, isolicoflavonol is a promising natural compound with potential health benefits, but further research is needed to fully understand its mechanisms of action and potential therapeutic applications.

Upstream product

• 90-24-4 2-hydroxy-4,6-dimethoxyacetophenone 
• 480-66-0 2,4,6-trihydroxyacetophenone 
• 67-56-1 methanol 
• 59259-80-2 3,5,7-trimethoxy-4'-hydroxyflavonol 
• 132020-80-5 4'-(benzyloxy)-3,5,7-trimethoxyflavone 
• 22812-15-3 2-[4-(benzyloxy)phenyl]-5,7-dimethoxy-4H-chromen-4-one 
• 108-73-6 3,5-dihydroxyphenol 
• 19158-99-7 2’,4’-dimethoxy-6’-hydroxy-4-O-benzylchalcone 

Relevant articles and documents

Synthesis method of isolicoflavonol

The invention provides a synthesis method of isolicoflavonol, which comprises the following steps: carrying out condensation reaction on 2,4-O-R1(protective group, the same below)-6-hydroxyacetophenone and 4-O-R2(protective group, the same below)-benzaldehyde to generate 2',4'-O-R1-6'-hydroxy-4-O-R2-chalcone; oxidizing the chalcone to generate flavonol; carrying out selective protection on 3-OH ofthe flavonol to obtain 3,5,7-O-R1-4'-O-R2-flavonol; removing the protecting group R2 from the 3,5,7-O-R1-4'-O-R2-flavonol to obtain 3,5,7-O-R1-4'-hydroxyflavonol; carrying out 1,1-dimethylpropargyl reaction on the 4,4'-OH site to obtain 3,5,7-O-R1-4'-O-(1',1''-dimethyl propargyl)flavonol; carrying out partial hydrogenation on the alkynyl of the 3,5,7-O-R1-4'-O-(1',1''-dimethyl propargyl)flavonolunder the action of a catalyst to obtain 3,5,7-O-R1-4'-O-(1',1''-dimethylpropenyl)flavonol and carrying out Claisen rearrangement on the 3,5,7-O-R1-4'-O-(1',1''-dimethylpropenyl)flavonol to obtain 3,5,7-O-R1-isolicoflavonol, and removing the protecting group R1 from the 3,5,7-O-R1-isolicoflavonol to obtain the isolicoflavonol.