94806-35-6Relevant articles and documents
The organocatalytic asymmetric prins cyclization
Tsui, Gavin Chit,Liu, Luping,List, Benjamin
, p. 7703 - 7706 (2015)
We describe here the design and development of an organocatalytic Prins cyclization. In the presence of a confined chiral imidodiphosphoric acid catalyst, salicylaldehydes react with 3-methyl-3-buten-1-ol to afford highly functionalized 4-methylenetetrahydropyrans in excellent regio- and enantioselectivity. The extreme steric demand of the acid catalyst is key for the success of this transformation. A bulky cat.: In an organocatalytic asymmetric Prins cyclization, salicylaldehydes react with 3-methyl-3-buten-1-ol in the presence of a chiral imidodiphosphoric acid catalyst to afford highly functionalized 4-methylenetetrahydropyrans in excellent regio- and enantioselectivities (see scheme).