948092-68-0Relevant articles and documents
Design and synthesis of a new class of selective integrin α5β1 antagonists
Stragies, Roland,Osterkamp, Frank,Zischinsky, Gunther,Vossmeyer, Doerte,Kalkhof, Holger,Reimer, Ulf,Zahn, Grit
, p. 3786 - 3794 (2008/02/11)
Starting from the structure of integrin αvβ3 in a complex with a peptidic ligand plus SAR data on nonpeptidic ligands, we derived a new class of integrin α5β1 antagonists (1). Several synthesis strategies were applied to evaluate the chemical space around